PANCE Blueprint Genitourinary (5%)

Patient with stress incontinence will present as → a 68-year-old woman who presents to your office with leakage of urine when she sneezes, laughs, or coughs. She reports that these symptoms strictly occur during the day and never at night. She denies any subjective fever, dysuria, or hematuria. Pelvic examination is notable for a protrusion from the anterior vagina.

Patient with urge incontinence will present as → a  55-year-old woman comes to your clinic complaining of frequent episodes of sudden, intense urges to urinate that she cannot control, leading to urinary leakage. She reports that these episodes occur both during the day and at night. She denies any dysuria, hematuria, or fever. She has no significant past medical history and takes no medications. Physical examination, including a pelvic exam, is unremarkable. Urinalysis is normal

Patient with overflow incontinence will present as → a 68-year-old man with a history of benign prostatic hyperplasia and diabetes mellitus presents to your clinic complaining of frequent dribbling of urine and a sensation of incomplete bladder emptying. He also reports difficulty initiating urination and a weak urinary stream. Physical examination reveals a distended, non-tender lower abdomen. Post-void residual urine volume is measured at 350 mL.

Patient with functional incontinence will present as → a 78-year-old woman with a history of osteoarthritis and mild cognitive impairment is brought to your clinic by her daughter. The daughter reports that her mother has been experiencing episodes of urinary incontinence, especially when she tries to get to the bathroom. The patient uses a walker and takes time to get out of her chair. She denies any urgency, frequency, or nocturia. Physical examination and laboratory tests, including urinalysis, are unremarkable.

Patient with enuresis will present as → a mother and her 6-year-old son come to the office with a concern that he continues to have nighttime wetting several times a week. He is the second child of three. He is in the first grade and struggling with his performance. He has had no medical problems. There is no history of developmental delay, and he was the product of a normal uncomplicated pregnancy and delivery. Since the birth of the third child, his behavior has been problematic. The examination of other body systems is normal. He does not have laboratory evidence of a urinary tract infection.

There are five major types of incontinence - affects 30% of elderly women and 15% of elderly men

1. Urge incontinence (detrusor overactivity)

• Most common in elderly and nursing home patients
• Overactive detrusor muscle results in increased frequency and involuntary loss of urine
• Sudden urge to urinate (e.g., patients are unable to make it to the bathroom), a loss of large volumes of urine with small postvoid residual, and nocturnal wetting
• Diagnostic study of choice is a urodynamic study

2. Stress incontinence (weakness of pelvic floor)

• Occurs mostly in women (after multiple deliveries of children)
• Weakness of the pelvic diaphragm (pelvic floor) leads to loss of bladder support (with resultant hypermobility of the bladder neck). This causes the proximal urethra to descend below the pelvic floor so that an increase in intra-abdominal pressure is transmitted mostly to the bladder (instead of an equal transmission to the bladder and urethra)
• Involuntary urine loss (only in spurts) during activities that increase intra-abdominal pressure (cough, laugh, sneeze, exercise); small postvoid volume
• Rule out infection with a urinalysis

3. Overflow incontinence (impaired detrusor contractility) cannot empty bladder - high postvoid volume

• Common in diabetic patients and patients with neurologic disorders
• Inadequate bladder contraction (due to impaired detrusor contractility) or a bladder outlet obstruction leads to urinary retention and subsequent overdistention of the bladder. Bladder pressure increases until it exceeds urethral resistance, and urine leakage occurs
• Causes include neurogenic bladder (diabetic patients, lower motor neuron lesions), medications (anticholinergics, α-agonists, and epidural/spinal anesthetics), obstruction to urine flow (BPH, prostate cancer, urethral strictures, severe constipation with fecal impaction)
• Nocturnal wetting, frequent loss of small amount of urine; large postvoid residual (usually exceeds 100 mL)

4. Functional incontinence - occurs in patients who have normal voiding systems, but who have difficulty reaching the toilet because of physical or mental disabilities

• Symptoms include increased urinary volume and the inability to timely urinate

5. Mixed incontinence (combo of stress and urge) - most common

Urinalysis to rule out UTI

• Postvoid residual urine volume to identify urinary retention
  • Overflow has a high PVR
  • Stress and urge have a normal/low PVR
• Urodynamic studies can identify bladder contractions
  • Stress - normal bladder contractions
  • Urge - increased bladder contractions during the filling phase
• Ultrasonography and cystoscopy can be used to determine anatomic abnormalities

1. Urge incontinence (detrusor overactivity) is treated with bladder-training exercises (the goal is to increase the amount of time between voiding)

• If this is unsuccessful, medications include Beta-3 adrenergic agonist drugs (mirabegron and vibegron) and antimuscarinic agents (oxybutynin and solifenacin)
  • Mirabegron is preferred over antimuscarinics like oxybutynin or solifenacin due to its lower side effect profile.

2. Stress incontinence (weakness of pelvic floor) is treated with Kegel exercises (multiple contractions of pelvic floor muscles as if patient were interrupting flow of urine) to strengthen pelvic floor musculature

• Vaginal estrogens
• Use of a pessary
• Surgery (there are various options, and a popular option is a mid-urethral sling)

3. Overflow incontinence (impaired detrusor contractility)

Treatment is primarily medical: intermittent self-catheterization is the best management

• cholinergic agents (e.g., bethanechol) to increase bladder contractions
• α-blockers (e.g., terazosin, doxazosin) to decrease sphincter resistance

4. Functional incontinence is treated with scheduled voiding times

5. Mixed - (combo of stress and urge) most common

• Lifestyle modifications and pelvic floor exercises are first-line
• If unresponsive to first-line treatments then therapy is based on the predominant symptoms