Cervical Dysplasia: The Daily PANCE Blueprint
A 33-year-old G0P0 female with a history of hypothyroidism and tobacco abuse presents to the clinic for an annual well-woman visit. Her Pap smear demonstrates high-grade cervical intraepithelial neoplasia. Which of the following is the strongest risk factor for developing this precancerous condition?
A. HPV infection
B. Early menarche
C. Tobacco usage
D. Long-term OCP usage
E. Multiple sex partners
Answer and topic summary
The answer is A. HPV infection
Cervical intraepithelial neoplasia (CIN) is a pre-malignant cervical lesion defined by epithelial dysplasia. It is diagnosed by cervical biopsy and histologic examination. It can end up progressing to invasive cervical carcinoma. Human papillomavirus (HPV) is the strongest risk factor for cervical precancer and cervical cancer. There are various classifications: CIN I (mild dysplasia, involving 1/3 of basal epithelium), CIN II (moderate dysplasia, involving 1/3-2/3 of basal epithelium) and CIN III (severe, irreversible dysplasia or carcinoma in situ, >2/3 of basal epithelium). The American Society of Colposcopy and Cervical Pathology (ASCCP) guidelines of 2019 should be followed for work-up.
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Covered under ⇒ PANCE Blueprint Reproductive System ⇒ ⇒
Also covered as part of the Women's Health Rotation topic list
