PANCE Blueprint Neurology (6%)

Lessons

1. Neurology Flashcards (Members Only)

2. Cranial Nerves (Picmonic)
3. Diseases of Peripheral Nerves (PEARLS)
   1. Complex regional pain syndrome

      Non-dermatomal limb pain usually following a trauma or surgery. Upper or lower limbs pain, swelling, reduced range of motion, skin changes, and bone demineralization

      • Pain is disproportionate to the injury with continuing pain that is disproportionate to any inciting event
      • Sensory: hyperalgesia and/or allodynia
      • Vasomotor: skin, temperature, color asymmetry
      • Sudomotor/edema: edema, sweating changes, or sweating asymmetry
      • Motor/trophic: decreased range of motion or motor dysfunction and/or trophic changes (hair, nail, skin)
   2. Peripheral neuropathies

      Symmetric distal sensory loss along with burning pain or weakness

      • Slow onset in stocking glove (hands and feet) pattern think Diabetes mellitus, uremia
      • Fast onset think drugs
      • Ascending think Guillain-Barre Syndrome
4. Neurology Comprehensive Exam (Members Only)
5. Headaches (PEARLS)
   1. Brian Wallace PA-C Podcast: Headaches

      16 mins

      Brian Wallace PA-C
   2. Cluster headache

      Severe, unilateral, periorbital pain, lacrimation, and nasal congestion

      • More common in men (4:1). Treatment: 100% oxygen
   3. Migraine (ReelDx)

      Unilateral (70%), throbbing, disabling pain, nausea, vomiting, photophobia

      • Classic: Aura and Common: No aura (80% of migraines)
      • Abortive: Triptans (do not use in ischemic heart disease), ergotamine (do not use in pregnant women)
   4. Tension headache (ReelDx)

      Bilateral, non-throbbing, band-like or "vice like" pain

      • A tension-type headache is typically described as bilateral, mild to moderate, dull pain, whereas a migraine is typically pulsating; unilateral; and associated with nausea, vomiting, and photophobia or phonophobia.
      • Treatment: NSAIDs, Excedrin, muscle relaxer
6. Infectious Neurologic Disorders (PEARLS)

   1. Brian Wallace PA-C Podcast: Infections and movement disorders

      23 mins

      Brian Wallace PA-C
   2. Encephalitis

      May present similar to meningitis but will see altered mental status, seizures, personality changes, exanthema. Encephalitis is clinically differentiated from meningitis by altered brain functioning.

      • Usually viral: Most common species: HSV or Immunocompromised: CMV
   3. Meningitis (ReelDx)

      Classic Triad: Fever, headache, stiff neck, petechiae (especially N. meningitidis)

      • Kernig's sign: knee extension causes pain in neck (Remember K = Kernig's and K = Knee)
      • Brudzinski's sign: leg raise when bend neck
      • CSF Finding: 
        • Bacterial: ↑ Protein ↓ Glucose (bacteria love to eat glucose)
          • there is a markedly increased opening pressure
        • Viral:  normal pressure, increased WBC (lymphocytes)
7. Movement Disorders (PEARLS)

   1. Brian Wallace PA-C Podcast: Parkinsons and Intracranial hemorrhages

      25 mins

      Brian Wallace PA-C
   2. Essential tremor

      Bilateral intention tremor of the hands, forearm, and/or head without resting component

      • Family history in 50-70% of patients, autosomal dominant inheritance. Elderly patients
      • Worse on intention. Hands and head.
      • Better with alcohol
      • Less likely to be unilateral
   3. Huntington Disease

      Inherited autosomal dominant neurodegenerative disease characterized by progressive motor and psychiatric dysfunction, dementia, and chorea (nonrepeating, complex, involuntary rhythmic movements that may appear purposeful)

      • Genetic testing: 40+ CAG repeats
   4. Parkinson disease

      Resting/pill rolling tremor, masked facies,  cogwheel (catching and releasing), bradykinesia, and shuffling gait

      • Decreased dopamine in substantia nigra. Lewy bodies.
8. Vascular Disorders (PEARLS)

   1. Brian Wallace PA-C Podcast: Vascular disorders

      33 mins

      Brian Wallace PA-C
   2. Cerebral aneurysm

      Weak, bulging spot on the wall of a brain artery very much like a thin balloon or weak spot on an inner tube.

      • Usually found either incidentally or when a patient presents with subarachnoid hemorrhage.
      • Before a larger aneurysm ruptures, the individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.
      • A key symptom of a ruptured aneurysm is a sudden, severe headache (the worst headache of my life).
      • Types include Saccular (Berry), Fusiform, dissecting, mycotic, and traumatic.
      • Ruptured saccular (berry) aneurysm accounts for approximately 75% of nontraumatic cases of SAH and has a mortality rate of 50%.
      • Noncontrast head CT is the initial investigational modality for suspected SAH.
        • Lumbar Puncture (LP) with evaluation of CSF reveals markedly elevated opening pressures and RBC in CSF. Xanthochromia (CSF protein > 150 mg/dL or serum bilirubin > 6 mg/dL) - if the blood has been in the CSF for over 2 hours.
        • Cerebral angiography (Gold Standard) should be done to evaluate the entire vasculature.
      • Surgical clipping or endovascular coiling is usually performed within the first 24 hours.
   3. Intracranial hemorrhage (ReelDx)

      • Epidural Hematoma:  transient loss of consciousness from an injury, period of lucency, then neurologic deterioration. CT: lens-shaped, biconvex
      • Subdural Hematoma: elderly patient with a history of multiple falls who is now presenting with neurological symptom. May be chronic, taking days to weeks to develop symptoms. CT scan: Crescent shaped density in the brain
      • Subarachnoid hemorrhage: "explosive thunderclap" headache described as "the worst headache ever." Aneurysm or AVM rupture.
   4. Stroke (ReelDx)

      Acute onset of focal neurologic deficits resulting from - diminished blood flow (ischemic stroke) or hemorrhage (hemorrhagic stroke).

      • Contralateral paralysis, motor function. Right-sided symptoms = left side stroke, Left-sided symptoms = right side stroke.
        • Carotid/Ophthalmic: Amaurosis fugax (monocular blind).
        • MCA:  Aphasia, neglect, hemiparesis, gaze preference, homonymous hemianopsia.
        • ACA:  Leg paresis, hemiplegia, urinary incontinence.
        • PCA: homonymous hemianopsia.
        • Basilar Artery: Coma, cranial nerve palsies, apnea, drop attach, vertigo.
        • Lacunar infarcts occur in areas supplied by small perforating vessels and result from atherosclerosis, hypertension, and diabetes: Silent, pure motor or sensory stroke, "Dysarthria-Clumsy hand syndrome", ataxic hemiparesis.
      • CT without contrast for acute presentation - important to diagnose as ischemic or hemorrhagic.
      • For occlusive disease treat with IV tPA if within 3-4.5 hours of symptom onset.
        • Can consider intra-arterial thrombolysis in select patients (major MCA occlusion) up to 6 hours after onset of symptoms.
        • For embolic disease and hypercoagulable states give warfarin/aspirin once the hemorrhagic stroke has been ruled out.
        • Endarterectomy if carotid > 70% occluded.
   5. Transient ischemic attack

      An episode of neurologic dysfunction due to focal brain, retinal, or spinal cord ischemia without acute infarction.

      • Large artery low flow TIA (stenosis) likely carotid stenosis causing short live (minutes) decrease in flow to the brain.
      • Embolic TIA: emboli often form in the heart (afib)(septic emboli from endocarditis).
      • Clinical Manifestations:
        • Internal carotid artery: Amaurosis Fugax (monocular vision loss - temporary "lampshade down on one eye") weakness in the contralateral hand.
        • ICA/MCA/ACA: Cerebral hemisphere dysfunction. Sudden headache, speech changes, confusion.
        • PCA: somatosensory deficit.
        • Vertebrobasilar: brainstem/cerbral syumpstoms (gait and proprioception) .
      • Diagnose by CT (without contrast), MRI more sensitive, carotid doppler to look for stenosis, CT angiography, MR angiography.
      • Carotid endarterectomy if internal or common carotid artery stenosis is > 70%.
      • Aspirin within 24 hours. Antiplatelet therapy (e.g., aspirin or clopidogrel or aspirin-dipyridamole) should be then initiated.
9. Other Neurologic Disorders (PEARLS)

   1. Brian Wallace PA-C Podcast: Other Neurological Disorders

      80 mins

      Brian Wallace PA-C
   2. Altered level of consciousness (ReelDx)

      1. Eye opening:

      • 4- spontaneous
      • 3- voice
      •  2-pain
      • 1-none

      2. Verbal:

      • 5-oriented
      • 4-confused
      • 3-inappropriate words
      • 2-incomprehensible
      • 1-none

      3. Motor:

      • 6-obeys commands
      • 5-localizes pain
      • 4-withdraws
      • 3-abnormal flexion (decorticate)
      • 2-abnormal extension (decerebrate)
      • 1-none

      Scoring

      • Maximum score is 15 which has the best prognosis
      • Minimum score is 3 which has the worst prognosis
      • Less than 9 is a coma
   3. Cerebral palsy (ReelDx)

      13 mins

      Prenatal injury perinatal hypoxia or ischemia, preterm baby

      • Hyperreflexia, rigidity, intellectual impairment, seizures
   4. Concussion (ReelDx)

      Grade 1: No LOC, post traumatic amnesia and other symptoms resolve in < 30 minutes

      • Athlete may return to sports if asymptomatic for one week

      Grade 2: + LOC , 1 minute or post-traumatic amnesia and other symptoms last > 30 minutes but < 1 week

      • Athlete may return to sports in 2 weeks if asymptomatic at rest and exertion for at least 7 days

      Grade 3: + LOC > 1 minute or post-traumatic amnesia and other symptoms last > 1 week

      • Athlete may return to sports in 1 month if asymptomatic at rest and exertion for 7 days

      Repeat concussions: if associated with either loss of consciousness or symptoms for more than 15 minutes may NOT to return to play sports for that season
   5. Dementias

      • Alzheimer's disease Most common. Definitive diagnosis on autopsy - beta amyloid plaques and neurofibrillary tangles. Abnormal clock drawing test. Treat with Anticholinesterase drugs (Tacrine, Donepezil)
      • Vascular dementia (2nd most common type): Correlated with a cerebrovascular event and/or cerebrovascular disease. Stepwise deterioration with periods of clinical plateaus.
      • Lewy body dementia: Fluctuating cognition associated with parkinsonism, hallucinations and delusions, gait difficulties, and falls
      • Frontotemporal dementia: Personality changes precede memory changes.
   6. Delirium

      Acute, fluctuating mental status change caused by a medical condition

      • Delirium is rapid in onset, short term and reversible - Underlying organic cause: UTI, pneumonia, metabolic changes, CVA, MI, TBI, medications (anticholinergics, benzodiazepines, opioids). Treat underlying cause.
   7. Guillain-Barré syndrome

      Symmetrical ascending paralysis beginning in distal limbs, following Campylobacter jejuni infection, will often present after immunization

      • Weakness begins in lower extremities, treatment: admit, plasmapheresis or IVIG
      • Respiratory paralysis if no treatment. Good prognosis

   8. Multiple sclerosis (ReelDx)

      Autoimmune: Antibodies against myelin sheath: Often first finding: Retrobulbar optic neuritis. Other symptoms: numbness, tingling, balance disturbance, diplopia. MRI: Dawson fingers (white matter lesions). CSF: Elevated IgG, oligoclonal bands

      • Relapsing remitting MC 85% (symptoms come and go)
      • Secondary progressive (relapsing remitting progresses to steady decline)
      • Primary progressive (no remission, steady decline from onset)
      • Progressive relapsing (combination. Worse overtime with acute relapses. Most rare.)
   9. Myasthenia gravis (ReelDx)

      Autoimmune attack of acetylcholine receptors at the neuromuscular junction results motor problems

      • Young women, older men. weakness in everyday activities like brushing hair, Proximal to distal weakness: eyes: ptosis usually first
      • Diagnose with Acetylcholine receptor antibodies, Tensilon test/edrophonium test- short acting anticholinesterase
   10. Postconcussion syndrome

       Cognitive and/or behavioral manifestations that may be present for a few days to weeks following concussion, including:

       • Chronic headaches, short-term memory difficulties, fatigue, difficulty sleeping, personality changes (irritability, mood swings), and sensitivity to light and noise
       • Postconcussive symptoms typically resolve in a few days to several weeks
   11. Seizure disorders (ReelDx)

       Partial seizures: focal location in the brain affected often temporal lobe, the most common type of seizure in the elderly

       • Simple Partial: Consciousness fully maintained. Abnormal movements or sensations.
         •  Treatment: Carbamazepine
       • Complex Partial: Impaired consciousness lasts over 30 seconds, automatisms (ie. Lip smacking)
         •  Treatment: Carbamazepine

       Generalized seizures: start midbrain or brainstem and spreads to both cortices.

       • Absence seizure (petit mal): Children. Blank stare.
         • Treatment: Valproic acid, ethosuximide (only for absence)
       • Tonic clonic/Generalized convulsive (Grand mal): Loss of consciousness, increased muscle tone (tonic), jerking muscles (clonic).
         •  Postictal phase- confusion after seizure.
         •  Treatment: Valproic acid, carbamazepine
       • Myoclonic: muscle jerking, but not the tonic phase, occurs in the morning
       • Tonic: extreme rigidity then immediate LOC, but not followed by a clonic phase
       • Atonic attack (drop attack): looks like syncope, sudden loss of muscle tone

       Additional types

       • Febrile Seizure: A convulsion associated with an elevated temperature greater than 38°, > 6 mos < 5 years, absence of central nervous system infection or inflammation
         • Febrile seizures that continue for more than five minutes should be treated with IV benzodiazepines (diazepam or lorazepam)
   12. Status epilepticus

       A nonstop seizure lasting greater than 5 minutes. There are two types:

       • Generalized convulsive status epilepticus involves at least one of the following:
         • Tonic-clonic seizure activity lasting > 5 to 10 min.
         • ≥ 2 seizures between which patients do not fully regain consciousness.
       • Nonconvulsive status epilepticus includes complex partial status epilepticus and absence status epilepticus. They often manifest as prolonged episodes of mental status changes. EEG may be required for diagnosis.
   13. Syncope (ReelDx)

       Sudden, brief loss of consciousness (LOC) with loss of postural tone followed by spontaneous revival.

       • The patient is motionless and limp and usually has cool extremities, a weak pulse, and shallow breathing. Sometimes brief involuntary muscle jerks occur, resembling a seizure.
       • Near-syncope is light-headedness and a sense of an impending faint without LOC. It is usually classified and discussed with syncope because the causes are the same.
   14. Tourette disorder (ReelDx)

       The defining feature which separates Tourette syndrome from other tic disorders is the presence of both motor and vocal tics.

       • Symptoms must have been present for > 1 year and age at onset must be < 18 years old.
       • Tic disorders are divided into 3 categories:
         • Tourette syndrome (Gilles de la Tourette syndrome): Both motor and vocal tics have been present for > 1 year.
         • Persistent (chronic) tic disorder: Single or multiple motor or vocal tics (but not both motor and vocal) have been present for > 1 yr.
         • Provisional tic disorder: Single or multiple motor and/or vocal tics have been present < 1 yr.