PANCE Blueprint Renal System (5%)

PANCE Blueprint Renal System (5%)

PANCE Blueprint Renal System (5%)

Follow along with the NCCPA™ PANCE Renal System Content Blueprint

Lessons

  1. Renal Diseases (PEARLS)

  2. Acute Disorders (PEARLS)

    1. Glomerulonephritis (Lecture)

      Immune-mediated glomerular inflammation results in glomerular damage which results in urinary protein and RBC loss
      • Proteinuria, HTN, azotemia, oliguria (<400 ml urine/day), hematuria (RBC casts) hallmark, edema is not as much as nephrotic syndrome
      • Urinalysis: proteinuria < 3.5 grams per day, hematuria, RBC casts
      • Biopsy: hypercellular, immune complex deposition
      Etiologies of acute glomerulonephritis:
      • IgA Nephropathy (Berger disease): most common cause of acute glomerulonephritis worldwide - often affects young males within days  (24-48 hours) after URI or GI infection.
      • Postinfectious - Group A strep: 10-14 days after infection - diagnosed with ASO titers and low serum complement.
      • Membranoproliferative glomerulonephritis: due to SLE, viral hepatitis.
      • Rapidly progressive glomerulonephritis - crescent formation on biopsy due to fibrin and plasma protein deposition.
        • Goodpasture's syndrome: (+) anti-GBM antibodies, dx linear IgG deposits, treat with high dose steroids, plasmapheresis + cyclophosphamide.
        • Vasculitis: lack of immune deposits (+) ANCA antibodies.
    2. Glomerular damage results in increased urinary protein loss
      • Proteinuria, hypoalbuminemia, edema, hyperlipidemia, edema is predominant feature, transudative pleural effusion
      • Urinalysis: proteinuria > 3.5 grams on 24-hour urinefatty casts, oval fat bodies
      • Biopsy: hypo-cellular minimal change disease loss of podocytes on microscopy
      The most common primary causes are:
      • Membranous nephropathy: most common in non-diabetic adults associated with malignancies.
      • Minimal change disease: 80% of nephrotic syndrome in kids. Responds to corticosteroids.
      • Focal segmental glomerulosclerosis:  obese patients, heroin, and HIV black males.
      The most common secondary causes are:
      • Lupus: both nephritic and nephrotic.
      • Diabetes: common cause of nephrotic syndrome and subsequent renal failure.
      • Preeclampsia
    3. Irritative voiding + Fever + flank Pain + nausea and vomiting + CVA tenderness
      • Organism: E. coli
      • Urinalysis: Bacteria and WBC casts
      • Outpatient: ciprofloxacin/levofloxacin +/- ceftriaxone IM
      • Inpatient: Ciprofloxacin/levofloxacin or imipenem for more severe disease
  3. Acute renal failure (ReelDx + Lecture)

    Acute tubular necrosis (ATN)
    • Etiology: Kidney ischemia or toxins
    • Urinalysis: Muddy brown casts. Renal tubular epithelial cells + High Urine Osmolality
    • FENa > 2%
    Interstitial nephritis
    • Etiology: Immune-mediated response
      • Drugs: PCN, sulfa, NSAIDs, phenytoin etc.
      • Immunologic and infectious disease: strep, SLE, CMV, Sjogren's, Sarcoidosis
    • Urinalysis: WBC casts and eosinophils
    Glomerulonephritis
    • Etiology: IGA Nephropathy (Berger disease), postinfectious, membranoproliferative
    • Urinalysis: Oliguria, hematuria and RBC casts
  4. Chronic kidney disease

    CKD is a progression of ongoing loss of kidney function (GFR) defined as < 60 mL/min/1.73 m² or presence of kidney damage (proteinuria, glomerulonephritis or structural damage from polycystic kidney disease) for > 3 months.
    • Measurement of GFR is the gold standard - The Cockcroft - Gault formula (requires age, body weight, and serum creatinine) or Modification of Diet in Renal Disease equation
    • Etiology: Diabetes, hypertension, glomerulonephritis
    • Findings: Fatigue, pruritus, Kussmaul respirations, asterixis (flapping tremor), muscle wasting, broad waxy casts
  5. Congenital or structural renal disorders (PEARLS)

    1. Horseshoe kidney

      Horseshoe kidney, also known as renal fusion or super kidney, is a congenital disorder affecting about 1 in 500 people that is more common in men, often asymptomatic, and usually diagnosed incidentally
      • Congenital disorder affecting about 1 in 600 people, more common in men
      • Kidneys fuse together to form a horseshoe-shape during development in the womb
      • Often asymptomatic, though persons affected by this condition may experience nausea, abdominal discomfort, kidney stone, and urinary tract infections
      • The prevalence of horseshoe kidneys in females with Turner syndrome is about 15%
      • Commonly diagnosed incidentally on abdominal imaging, can be confirmed with US, CT, MRI, or intravenous pyelogram
      • Increased risk of renal cancer
      • No treatment required, may treat complications such as UTIs or kidney stones
    2. Hydronephrosis

      Urine outflow obstruction causes renal distention
      • Treat underlying cause
    3. Narrowing of one or both of the renal arteries, most often caused by atherosclerosis or fibromuscular dysplasia.
      • Renal Arteriography is Gold Standard for diagnosis
      • May hear a renal artery bruit on auscultation
      • Percutaneous transluminal angioplasty (PTA) plus stent placement or with surgical bypass of the stenotic segment
  6. End Stage Renal Disease (ESRD)

    End-stage renal disease (ESRD) is defined as a complete loss of kidney function for more than 3 months and is the last stage of chronic kidney disease
    • Stage 5 kidney failure GFR < 15 mL/min/1.73 m2
    • Low erythropoietin levels, no reticulocyte response occurs, typically a normochromic and normocytic anemia
    • Treatment includes dialysis and kidney transplant
    • Generally, dialysis is initiated when GFR < 10–15 mL/min
    • High serum parathyroid hormone
    • Low serum calcium
    • High serum phosphate
    • High serum potassium
    • Waxy casts with very low urine flow are findings in end-stage renal disease
    • Hypertension due to salt and water retention, and increased renin in response to low GFR
    • Metabolic acidosis ↑ K+, ↑ phos, ↓ Na+, ↓ HCO3, ↓ Ca2+
    • Pericarditis is a cardiac complication that requires urgent dialysis
    • Loop diuretics are the preferred addition to the management of edema associated with hypertension due to chronic kidney disease
    1. Acid/Base Disorders (PEARLS)

      Average values "24/7 40/40"
      • 24 (HCO3, base) / 7.40 (pH) / 40 (CO2, acid)
      Respiratory Acidosis:
      • pH < 7.35, pCO2 > 45, HCO3 > 26
      • Lungs fail to excrete CO2 (Breathing too slow (holding onto CO2), pulmonary disease, neuromuscular disease, drug-induced hypoventilation - opiates, barbiturates)
      Respiratory Alkalosis:
      • pH > 7.45, pCO2 < 35, HCO3 < 22
      • Excessive elimination of CO2 (Breathing too fast (blowing of CO2), pulmonary embolism, fever, hyperthyroid, anxiety, salicylate intoxication, septicemia )
      Metabolic Acidosis
      • pH <7.35, pCO2 < 35, HCO3 < 22
      • Need to calculate anion gap: Anion Gap = Na – (Cl + HCO3-) = 10-16
      • Increased ion gap (>16): Addition of hydrogen ions (lactic acidosis (think metformin), diabetic ketoacidosis, aspirin overdose)
        •  MUDPILES:
          • Methanol
          • Uremia
          • Diabetic Ketoacidosis
          • Paraldehyde
          • Infection
          • Lactic Acidosis
          • Ethylene Glycol
          • Salicylates
      • Low anion gap (<16): Loss of bicarbonate (diarrhea, pancreatic or biliary drainage, renal tubular acidosis)
      Metabolic Alkalosis:
      • pH > 7.45, pCO2 > 45, HCO3 > 26
      • Loss of hydrogen (vomiting), bulimia, overdose of antacids, addition of bicarbonate (hyperalimentation therapy)
    2. Dehydration

      Dehydration is caused by not drinking enough fluid or when body fluids are lost from the extracellular compartment at a rate that exceeds intake
      • Fluid can be lost from the GI tract (diarrhea, vomiting), kidneys (urinating), or skin (sweating, fever), third spacing in the abdomen (ascites), or from injured tissues (burns)
      • Mild volume depletion can cause increased heart rate, fatigue, and muscle cramps
      • Moderate fluid loss causes dizziness and hypotension when standing
      • Severe hypovolemia results in general hypotension, signs of ischemia and shock, and lethargy and confusion
      • On physical exam look for a delayed capillary refill, dry mucous membranes, and elevated pulse rate
      • Hematocrit and serum albumin may be increased in volume-depleted patients
        • Urinary sodium decreases and urine osmolality increases 
        • Urea increases (secondary to urine stasis in the nephron), but there is little change in serum creatinine
        • Serum bicarbonate is the most useful laboratory test to assess the degree of dehydration in children
      • Treatment depends on the level of dehydration
        • Mild: oral rehydration for patients with
        • Moderate: Administering 50 mL to 100 mL of oral rehydration solutions per kilogram per body weight during two to four hours to replace the estimated fluid deficit, with additional oral rehydration solution, administered to replace ongoing losses
        • Severe Dehydration
          • Rapid restorations of fluids are required - start with 20 ml/kg boluses of normal saline
          • Multiple boluses may be needed for children in hypovolemic shock
    3. Hyperkalemia/hypokalemia (Lecture)

      Hyperkalemia
      • Definition: serum potassium of > 5-5.5 mEq/L
      • Presentation: Peaked T waves, prolonged QRS, muscle fatigue
      • Treatment: Insulin, sodium bicarbonate, and glucose (drive potassium back into the cell). Calcium gluconate (antagonize effect of potassium on heart)
      Hyokalemia
      • Definition: serum potassium of < 3.5 mEq/L
      • Presentation: Muscle cramps, constipation, flattened/inverted T waves, U waves
      • Treatment: Potassium repletion - DO NOT use dextrose-containing fluids as this will stimulate insulin release and shift potassium within the cell which worsens the hypokalemia. Replace magnesium in magnesium deficiency
    4. Hypervolemia

      Hypervolemia, also known as fluid overload, is the medical condition where there is too much fluid (plasma) in the blood
      • Hypervolemia can be caused by failure of the heart, kidney, or liver, or by a high-salt diet
      • Symptoms include weight gain, swelling, and shortness of breath
      • The cause of hypervolemia may be apparent based on patient history (e.g. CKD, CHF, Cirrhosis)
        • Urine dipstick for protein, and measure serum creatinine, serum albumin, prothrombin time, liver function tests, and TSH
        • EKG, echocardiogram, ultrasonography
        • Chest X-Ray
      • Treatment depends on the cause, dietary sodium and fluid restriction, diuretics (furosemide), dialysis (ultrafiltration)
      • Monitor urine output and daily weights, and consider Swan–Ganz catheter placement depending on the patient’s condition
    5. Hyponatremia

      Hyponatremia / Hypervolemia: serum sodium of < 135 mmol/L
      • Presentation: Muscle cramps and seizures
        • Hypervolemic hyponatremia – CHF, nephrotic syndrome, renal failure, cirrhosis
        • Euvolemic hyponatremia – SIADH (Picmonic), steroids, hypothyroid
        • Hypovolemic hyponatremia – sodium loss (renal, non-renal)
      • Serum Na should be corrected slowly—by ≤ 10 mEq/L over 24 h to avoid osmotic demyelination syndrome
  7. Neoplastic Diseases of the Renal System (PEARLS)

    1. Renal cell carcinoma (Lecture)

      Classic triad of flank pain + hematuria + painless abdominal/renal mass
      • Renal clear cell carcinoma is the most common type (80%)
      • Transitional cell is the second most common type (20%)
      • Smoking is the most significant risk factor
    2. Wilms tumor (ReelDx + Lecture)

      Child with painless, unilateral abdominal mass with no other signs of symptoms, also known as nephroblastoma.

The Daily PANCE and PANRE

Get 60 days of PANCE and PANRE Multiple Choice Board Review Questions delivered daily to your inbox. It's 100% FREE and 100% Awesome!

You have Successfully Subscribed!