Glomerulonephritis: The Daily PANCE Blueprint

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Glomerulonephritis: The Daily PANCE Blueprint

What pathologic process causes renal damage in post-streptococcal glomerulonephritis (PSGN)?

A. Direct bacterial invasion of the glomerulus
B. Deposition of immune complexes in the glomerular basement membrane
C. Activation of T cells leading to direct cytotoxicity
D. Direct antibody-mediated attack on glomerular endothelial cells
E. Overproduction of nephrotoxic cytokines by mesangial cells

Answer and topic summary

The answer is B. Deposition of immune complexes in the glomerular basement membrane

In PSGN, renal damage is caused by the deposition of immune complexes composed of streptococcal antigens and host antibodies in the glomerular basement membrane. This leads to activation of the complement system and recruitment of inflammatory cells, resulting in glomerular inflammation and injury. This process is the hallmark of immune-complex-mediated glomerulonephritis, which is commonly observed after group A streptococcal infections of the throat.

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Covered under ⇒ PANCE Blueprint Renal System ⇒ Acute Disorders ⇒ Glomerulonephritis 

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