Hemochromatosis: The Daily PANCE Blueprint
Which of the following is the most common cause of death in hemochromatosis?
A. Hepatocellular carcinoma
B. Diabetic-related complications
C. Acute respiratory failure
D. Left ventricular failure
E. Pancreatic cancer
Answer and topic summary
The answer is A. Hepatocellular carcinoma
Hemochromatosis is an autosomal recessive disorder defined by excessive iron deposition in the liver, pancreas, and heart. It is often caused by a mutation in the HFE gene. Clinical features include skin hyperpigmentation, weakness, hepatomegaly, liver function abnormality, and diabetes mellitus.
Lab findings will show elevated serum iron, elevated ferritin, elevated transferrin saturation percentage, and decreased transferrin. Diagnostic tests include genetic testing and liver biopsy (gold standard, not always needed). Treatment consists of life-long phlebotomy. The most common cause of death in these patients is hepatocellular carcinoma.
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Covered under ⇒ PANCE Blueprint Hematology ⇒ ⇒
