Pemphigus Vulgaris: The Daily PANCE Blueprint
Which of the following is the most appropriate treatment option for moderate to severe pemphigus vulgaris?
A. Topical corticosteroids
B. Rituximab therapy
C. Narrowband UV phototherapy
D. Systemic corticosteroids
E. Both B and D combined
Answer and topic summary
The answer is E. Both B and D combined
Pemphigus vulgaris is a life-threatening dermatologic disorder characterized by blister formation in the skin and mucous membranes. It is classified as a Type II hypersensitivity reaction. Precipitating factors include dietary changes, UV radiation, viral infections, and certain medications (e.g., captopril or penicillamine). Clinical features may include painful, flaccid blisters (commonly with mucosal involvement), erosions, and crusts. The Nikolsky sign (mechanical pressure at the edge of blisters leads to induction of blistering and sloughing off of epidermis/skin) will be positive. Diagnosis is confirmed with a biopsy. Rituximab combined with systemic corticosteroids is now the most appropriate first-line treatment for moderate-to-severe pemphigus vulgaris.
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Covered under ⇒ PANCE Blueprint Dermatology ⇒ ⇒
