Biliary Disorders: The Daily PANCE Blueprint

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Biliary Disorders: The Daily PANCE Blueprint

A 40-year-old male presents with fatigue, pruritus, and jaundice. He has a history of ulcerative colitis. Laboratory findings reveal elevated alkaline phosphatase and gamma-glutamyl transferase levels. Magnetic Resonance Cholangiopancreatography (MRCP) shows irregular narrowing and dilation of both intrahepatic and extrahepatic bile ducts. Which of the following is the most likely diagnosis?

A. Primary Biliary Cirrhosis (PBC)
B. Primary Sclerosing Cholangitis (PSC)
C. Cholangiocarcinoma
D. Autoimmune Hepatitis
E. Gallstone Disease

Answer and topic summary

The answer is B. Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis is a chronic liver disease characterized by progressive inflammation and scarring of the bile ducts. This patient’s presentation of fatigue, pruritus, and jaundice, along with the history of ulcerative colitis, and characteristic MRCP findings of “beading” in the bile ducts (irregular narrowing and dilation) strongly suggest PSC.

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Covered under ⇒ PANCE Blueprint GI and Nutrition ⇒ Biliary Disorders ⇒ Cholangitis