Cervical Dysplasia: The Daily PANCE Blueprint
Which of the following best describes CIN III?
A. Mild dysplasia involving the lower one-third of the epithelium
B. Moderate dysplasia involving one-third to two-thirds of the epithelium
C. Severe dysplasia or carcinoma in situ involving more than two-thirds of the epithelium
D. Invasive cervical carcinoma extending beyond the basement membrane
Answer and topic summary
The answer is C. Severe dysplasia or carcinoma in situ involving more than two-thirds of the epithelium
Cervical intraepithelial neoplasia (CIN) is a pre-malignant cervical lesion defined by epithelial dysplasia. It is diagnosed by cervical biopsy and histologic examination. It can end up progressing to invasive cervical carcinoma. Human papillomavirus (HPV) is the strongest risk factor for cervical precancer and cervical cancer. There are various classifications: CIN I (mild dysplasia, involving 1/3 of basal epithelium), CIN II (moderate dysplasia, involving 1/3-2/3 of basal epithelium) and CIN III (severe, irreversible dysplasia or carcinoma in situ, >2/3 of basal epithelium). The American Society of Colposcopy and Cervical Pathology (ASCCP) guidelines of 2019 should be followed for work-up.
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Also covered as part of the Women's Health Rotation topic list
