G6PD Deficiency: The Daily PANCE Blueprint
A 28-year-old African American man presents to the emergency department with complaints of dark urine and fatigue for 2 days. His symptoms began after starting dapsone for dermatitis herpetiformis. He had never taken this medication before and was unaware of any medication allergies. He denies any other medical history. On examination, he appears pale with mild jaundice. His heart rate is 98/min, blood pressure is 110/65 mm Hg, respirations are 20/min, and temperature is 37.4°C (99.3°F). Laboratory studies show an elevated lactate dehydrogenase level, indirect bilirubin level, and a decreased hemoglobin level with the presence of bite cells and Heinz bodies on peripheral smear. What is the patient's most likely diagnosis?
A. Autoimmune hemolytic anemia
B. Hereditary spherocytosis
C. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
D. Sickle cell anemia
E. Thalassemia
Smarty PANCE Content Blueprint Review:
Covered under ⇒ PANCE Blueprint Hematology ⇒ Cytopenia's (PEARLS) ⇒ Hemolytic anemia (Lecture) ⇒ G6PD deficiency