Interstitial cystitis (IC): The Daily PANCE Blueprint

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Interstitial cystitis (IC): The Daily PANCE Blueprint

A 42-year-old woman presents with a 6-month history of pelvic pain, urgency, and frequency of urination. She reports that her symptoms worsen with the consumption of coffee and spicy foods. Urinalysis and urine culture are normal. Cystoscopy shows glomerulations after hydrodistention.Which of the following is the most appropriate initial treatment for this patient's condition?

A. Oral antibiotics
B. Intravesical botulinum toxin injection
C. Oral pentosan polysulfate
D. Immediate surgical intervention
E. High-dose oral corticosteroids

Answer and topic summary

The answer is C. Oral pentosan polysulfate

Oral pentosan polysulfate is considered a first-line treatment for interstitial cystitis/bladder pain syndrome (IC/BPS), a condition characterized by chronic pelvic pain, pressure, or discomfort related to the bladder, along with urinary frequency and urgency in the absence of other identifiable causes. Pentosan polysulfate works as a bladder protectant, helping to replenish the deficient glycosaminoglycan layer of the bladder urothelium, which is thought to be a contributing factor in IC/BPS. This treatment aims to reduce bladder wall irritation and alleviate symptoms.

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Smarty PANCE Content Blueprint Review:

Covered under ⇒ PANCE Blueprint Genitourinary ⇒ Bladder disorders (PEARLS) ⇒ Interstitial cystitis (IC) and bladder pain syndrome (BPS)