Pemphigus Vulgaris: The Daily PANCE Blueprint
Which of the following correctly defines Nikolsky sign?
A. Dislodgement of the superficial epidermis by shearing force
B. Pinpoint bleeding of papillary vessels after a scale is scrapped off
C. Physical stimuli leading to the appearance of new lesions
D. Pruritic erythema affecting the lateral aspects of the hips
E. Narrowed and paired white bands that run parallel to the lunula of the nails
Answer and topic summary
The answer is A. Dislodgement of the superficial epidermis by shearing force
Pemphigus Vulgaris is a life-threatening dermatologic disorder characterized by blister formation in the skin and mucous membranes. It is classified as a Type II hypersensitivity reaction. Precipitating factors include diet changes, UV radiation, viral infection, and drugs (e.g., captopril or penicillamine). Clinical features may include painful, flaccid blisters (commonly with mucosal involvement), erosions, and crusts. The Nikolsky sign (mechanical pressure at the edge of blisters leads to induction of blistering and sloughing off of epidermis/skin) will be positive. Diagnosis is confirmed with a biopsy. The first line is high-dose systemic steroids.
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Covered under ⇒ PANCE Blueprint Dermatology ⇒ ⇒
