Perioral dermatitis: The Daily PANCE Blueprint
A 25-year-old woman presents with a rash around her mouth that has been present for several weeks. She reports using a new moisturizer and a topical corticosteroid to treat the rash. Which of the following factors is most strongly associated with the development of perioral dermatitis?
A. Atopic dermatitis
B. Fluorinated toothpaste
C. Oral contraceptive pills
D. Topical corticosteroids
E. UV light exposure
Answer and topic summary
The answer is D. Topical corticosteroids
Topical corticosteroid use is one of the most significant risk factors for developing perioral dermatitis. Prolonged or inappropriate use of topical corticosteroids on the face can lead to a rebound inflammatory reaction when the steroids are discontinued, resulting in the characteristic papulopustular rash around the mouth. This is thought to be due to the immunosuppressive effects of the steroids disrupting the normal skin flora and barrier function. While other factors like fluorinated toothpaste, oral contraceptives, and atopic dermatitis have been suggested as potential contributors, the association with topical corticosteroids is the most well-established.
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Covered under ⇒ PANCE Blueprint Dermatology ⇒ ⇒
