Squamous cell carcinoma: The Daily PANCE Blueprint
Which of the following is the most significant risk factor for developing cutaneous squamous cell carcinoma (cSCC)?
A. Chronic arsenic exposure
B. Long-term UV radiation exposure
C. Ionizing radiation therapy
D. Chronic non-healing wounds
E. Alcohol use
Answer and topic summary
The answer is B. Long-term UV radiation exposure
Cutaneous squamous cell carcinoma (cSCC) occurs from the malignant transformation of keratinocytes of the epidermis. It is the 2nd MC type of skin cancer. Risk factors include UV exposure (most significant), ionizing radiation, chemical carcinogens, non-healing wounds, and precancerous lesions (like actinic keratosis). The classic presentation is a plaque-like lesion that eventually ulcerates (ulcers are usually red with everted edges) with adjacent inflamed/indurated skin. It occurs mostly on the face/neck. All skin lesions that are suspicious of cSCC should be biopsied. Treatment is surgical excision with a wide safety margin.
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Smarty PANCE Content Blueprint Review:
Covered under ⇒ PANCE Blueprint Dermatology ⇒ ⇒
Also covered as part of the General Surgery EOR topic list
