The Daily PANCE and PANRE Question 59

Which of the following is the earliest manifestation of diabetic nephropathy?

  1. proteinuria
  2. a progressive decline in the creatinine clearance
  3. an elevated serum haptoglobin
  4. renal insufficiency
  5. microalbuminuria

Answer: E


Tiny amounts of albumin (microalbumin) show up first - but need a special test ordered to detect it. Intervention at this point with an ACEI prolongs the length of time before the patient progresses to albuminuria (noted on a typical urine "dip")

Know Your Content Blueprint

Diabetes mellitus and its complications are part of the NCCPA Content Blueprint Endocrine System (6%)

Review diabetes mellitus pearls and flip through the high yield flashcards

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