Anorexia Nervosa: The Daily PANCE Blueprint

Anorexia Nervosa: The Daily PANCE Blueprint

A 19-year-old woman is brought in by her mother for eight months of increasingly restricted eating and compulsive daily exercise. Her BMI is 15.6 kg/m². She describes an intense fear of gaining weight and, shown a mirror, insists she still looks "too big." She has not had a period in five months. On examination her heart rate is 44, blood pressure is 86/54, her extremities are cool and mottled, and there is fine downy hair on her forearms with dry skin. There is no self-induced vomiting, no parotid swelling, and no dental erosion. Potassium is 3.5 mEq/L. Which of the following is the most likely diagnosis?

A. Bulimia nervosa
B. Avoidant/restrictive food intake disorder
C. Major depressive disorder with weight loss
D. Anorexia nervosa, restricting type
E. Hyperthyroidism

Answer and topic summary

The answer is D. Anorexia nervosa, restricting type

Restriction to a significantly low body weight, an intense fear of gaining weight, and a distorted experience of one’s own body is anorexia nervosa — and because there is no bingeing or purging, this is the restricting type. Note what the DSM-5 changed and what boards still test: amenorrhea is no longer required, though it is common and reflects hypothalamic suppression of GnRH. The physical findings are all the body slowing itself down to survive starvation: bradycardia and hypotension, cool mottled skin, hypothermia, and lanugo — that fine downy hair — along with amenorrhea and osteopenia from low estrogen. Management is multidisciplinary: nutritional rehabilitation and weight restoration first, with psychotherapy (family-based treatment is first-line for adolescents), and medical admission for severe bradycardia, hypotension, marked electrolyte derangement, or a very low weight. The complication you must know is refeeding syndrome: as carbohydrate returns, insulin drives phosphate, potassium, and magnesium into cells, and the resulting hypophosphatemia can cause cardiac failure, arrhythmia, seizures, and death. Refeed slowly, replace electrolytes, and monitor phosphate daily. No medication is approved for anorexia itself — and bupropion is contraindicated in eating disorders because of seizure risk. Separating the distractors: bulimia nervosa occurs at a normal or higher weight with recurrent binge-purge cycles, parotid enlargement, dental erosion, and Russell sign on the knuckles; ARFID involves food avoidance from sensory aversion, fear of choking, or lack of interest, without any body-image disturbance; depression causes appetite loss but not a drive for thinness; and hyperthyroidism would give tachycardia and heat intolerance rather than a pulse of 44.

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