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Psychiatry EOR: Neurodevelopmental Disorders (Pearls)

📌 2026 blueprint note: On the updated (July 2026) exam, this area is Neurodevelopmental Disorders; Dissociative Disorders — pair this page with the Dissociative Disorders Pearls. Conduct disorder and oppositional defiant disorder (below) were removed from the 2026 blueprint but remain testable on the legacy exam through July 2027.

NEURODEVELOPMENTAL DISORDERS
Attention-deficit/hyperactivity disorder
Patient will present as → an 8-year-old boy whose teacher reports he is disruptive in class, constantly fidgeting, blurts out answers, and never finishes assignments. His parents describe the same behavior at home since age 6.

An 8-year-old who is disruptive in class, constantly fidgeting, has difficulty concentrating, and does not complete assignments

  • Inattention, hyperactivity, and/or impulsivity that is developmentally inappropriate — combined, predominantly inattentive, or predominantly hyperactive/impulsive presentations
  • Highly comorbid with learning disorders, ODD, tics, and anxiety

DX: DSM-5≥ 6 symptoms of inattention and/or hyperactivity-impulsivity (≥ 5 if age ≥ 17) for > 6 months

  • Several symptoms present before age 12 and in ≥ 2 settings (home + school), with functional impairment
  • Clinical diagnosis — rating scales (Vanderbilt) from parents and teachers support it

TX: Age 4–5: parent training in behavior management first; age ≥ 6: stimulants first-line (methylphenidate, amphetamine salts) + behavioral therapy

  • Nonstimulant alternatives: atomoxetine, guanfacine ER, clonidine ER — comorbid tics, substance-use concern, or stimulant intolerance
  • Monitor growth, appetite, sleep, heart rate, and blood pressure on stimulants
Autism spectrum disorder
Patient will present as → a 2-year-old boy who does not respond to his name, avoids eye contact, and has no words. He spends hours lining up his toy cars and flaps his hands when excited. His M-CHAT-R screen at 24 months was positive.

Social-communication deficits + restricted, repetitive behaviors present from the early developmental period

  • DSM-5 folded the former subtypes (autistic disorder, Asperger, PDD-NOS) into one diagnosis, graded by support needs (levels 1–3)
  • Screen all children with the M-CHAT-R at 18 and 24 months (AAP)
  • Workup: audiology to exclude hearing loss; genetic testing (chromosomal microarray + fragile X) is standard of care

DX: DSM-5 — persistent deficits in all 3 social-communication domains (social-emotional reciprocity · nonverbal communication · relationships) + ≥ 2 of 4 restricted/repetitive patterns (stereotyped movements · insistence on sameness · fixated interests · sensory hyper/hyporeactivity)

  • Symptoms present in the early developmental period and cause functional impairment; not better explained by intellectual disability alone

TX: Early intensive behavioral intervention (ABA-based) + speech & language and occupational therapy

  • Medications treat targets, not autism: risperidone or aripiprazole — FDA-approved for irritability/aggression in ASD
  • Support families early — earlier intervention = better outcomes
Intellectual disabilities
Patient will present as → a 6-year-old boy with global developmental delay — first words at age 3, cannot dress himself, far behind peers in kindergarten. Exam shows a long face, prominent ears, and macroorchidism; his maternal uncle “needed special classes.”

Deficits in BOTH intellectual functioning AND adaptive functioning, with onset during the developmental period

  • Etiology pearls: Down syndrome = most common genetic cause · fragile X = most common inherited cause · fetal alcohol exposure = most common preventable cause
  • Mild severity is ~85% of cases — often not identified until school age
  • High rates of comorbid ADHD, autism, epilepsy, and behavioral disorders

DX: DSM-5 — deficits in intellectual functions (clinical assessment + standardized testing) AND adaptive functioning, with onset in the developmental period

  • Severity (mild → profound) graded by adaptive functioning — conceptual, social, practical domains — not IQ alone
  • Workup: hearing and vision first (sensory deficits masquerade as cognitive delay) → standardized IQ + adaptive assessment → chromosomal microarray + fragile X (FMR1) testing

TX: Early intervention services (before age 3) + an individualized education program (IEP)

  • Speech, occupational, and behavioral therapy; family support and care coordination; genetic counseling when a cause is found
  • No medication treats intellectual disability itself — treat comorbidities
Stereotypic movement disorder
Patient will present as → a 4-year-old boy who has flapped his hands and rocked his body since toddlerhood. The movements are rhythmic, look the same every time, and stop immediately when his name is called. Lately he has begun banging his head against the crib rail.

Rhythmic, purposeless, PATTERNED movements (hand flapping, body rocking, head banging) that STOP WITH DISTRACTION

  • vs tics: stereotypies start earlier (usually < 3 years vs ~5–7), are rhythmic and fixed in form, and lack a premonitory urge; tics are sudden, variable, urge-driven, and briefly suppressible
  • Common in autism and intellectual disability; benign "primary" stereotypies also occur in typical children
  • A parent video is often diagnostic — no EEG or imaging for classic distractible stereotypies

DX: DSM-5 — repetitive, seemingly driven, apparently purposeless motor behavior that interferes with activities or causes self-injury

  • Onset in the early developmental period; not attributable to a substance or neurologic condition and not better explained by OCD or trichotillomania
  • Specify: with or without self-injurious behavior; associated condition (e.g., intellectual disability)

TX: Behavioral intervention first-line — habit reversal and differential reinforcement + environmental modification

  • Self-injury: protective measures (padding, helmets) + intensive behavioral therapy
  • Medication has a limited role, reserved for severe self-injury; treat the underlying condition
Tic disorder
Patient will present as → a 9-year-old boy with eye blinking and shoulder shrugging plus repetitive throat clearing for 18 months, beginning at age 7. He describes a building urge relieved by the movement and can briefly hold the tics back in class, but they worsen with stress. His teacher also reports inattention.

Tourette disorder = BOTH multiple motor tics AND ≥ 1 vocal tic for > 1 year, onset before age 18

  • Tics are sudden, rapid, nonrhythmic, preceded by a premonitory urge, briefly suppressible, wax and wane, and worsen with stress — most decline in adolescence
  • Highly comorbid with ADHD and OCD — screen for both; they often impair the child more than the tics
  • Coprolalia occurs in a minority and is NOT required for Tourette

DX: DSM-5Tourette: multiple motor AND ≥ 1 vocal tic > 1 year, onset < 18, not attributable to a substance or medical condition

  • Persistent (chronic) tic disorder: motor or vocal tics (one type only) > 1 year · provisional: tics < 1 year since onset
  • Clinical diagnosis — rate severity/impairment (YGTSS) to decide whether treatment is needed at all

TX: Education + watchful waiting for mild tics; CBIT (Comprehensive Behavioral Intervention for Tics) first-line for impairing tics

  • Alpha-2 agonists (guanfacine, clonidine) treat both tics and comorbid ADHD; VMAT2 inhibitors or antipsychotics for debilitating tics
  • Stimulants are NOT contraindicated in tic disorders — treat comorbid ADHD with monitoring
DISRUPTIVE, IMPULSE-CONTROL AND CONDUCT DISORDERS
Conduct disorder
Patient will present as → a 13-year-old boy referred after he was caught setting fires and being cruel to a neighborhood cat. He has bullied classmates, stolen from stores, and stayed out all night despite prohibitions — a pattern for over a year.

A child is referred to your office for unusual animal cruelty and bullying at school

  • A repetitive pattern violating the basic rights of others or major age-appropriate norms — four categories: aggression to people/animals · destruction of property · deceitfulness or theft · serious rule violations
  • Often the precursor to antisocial personality disorder (which cannot be diagnosed before age 18)
  • vs ODD: ODD children are defiant but not aggressive to people/animals, destructive, or deceitful

DX: DSM-5≥ 3 of 15 criteria in the past 12 months (from any of the four categories), with ≥ 1 in the past 6 months

  • Specify childhood- vs adolescent-onset and "with limited prosocial emotions"; rule out substance use and abuse as drivers

TX: Multimodal psychosocial treatment integrating individual, school, and family settings

  • Parent management training has the best evidence; multisystemic therapy for severe cases
  • Treat comorbid ADHD, depression, and substance use — no medication treats conduct disorder itself
Oppositional defiant disorder
Patient will present as → a 9-year-old girl who constantly argues with her parents and teacher, refuses to follow rules, deliberately annoys classmates, and blames others for her mistakes — for the past 8 months. She has never been aggressive toward people or animals.

A child is found to backtalk and resist following instruction from parents or authorities

  • Three symptom clusters: angry/irritable mood · argumentative/defiant behavior · vindictiveness
  • vs conduct disorder: no aggression to people/animals, no property destruction, no theft or deceit

DX: DSM-5≥ 4 symptoms for ≥ 6 months, exhibited with ≥ 1 individual who is not a sibling

  • Often loses temper · easily annoyed · angry/resentful · argues with authority · defies rules · deliberately annoys · blames others · spiteful ≥ 2× in 6 months

TX: Psychosocial treatment first-lineparent management training (best evidence), CBT for anger/problem-solving, family therapy

  • No medication is approved for ODD itselftreat comorbid ADHD (stimulants often improve oppositional behavior)
  • Risperidone/aripiprazole reserved for severe, refractory aggression
Psychiatry EOR: Schizophreniform disorder (Prev Lesson)
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