Neoplastic Diseases of the Renal System: The Daily PANCE Blueprint

Neoplastic Diseases of the Renal System: The Daily PANCE Blueprint

A 58-year-old man presents with painless hematuria, a palpable mass in the abdomen, and unexplained weight loss. He has a history of smoking and hypertension. Which of the following is the most likely diagnosis?

A. Bladder cancer
B. Renal cell carcinoma
C. Prostate cancer
D. Urolithiasis (kidney stones)
E. Pyelonephritis

Answer and topic summary

The answer is B. Renal cell carcinoma

Renal cell carcinoma often presents with the classic triad of painless hematuria, a palpable abdominal mass, and unexplained weight loss. The patient’s history of smoking and hypertension are significant risk factors for RCC. This presentation is highly suggestive of renal cell carcinoma.

Explanation for Incorrect Answers:

  • A. Bladder cancer: Can present with hematuria but less likely to cause a palpable abdominal mass.
  • C. Prostate cancer: Typically presents with urinary symptoms and is not associated with hematuria or a palpable abdominal mass.
  • D. Urolithiasis: Causes painful hematuria, not typically associated with weight loss or a palpable mass.
  • E. Pyelonephritis: Presents with flank pain, fever, and urinary symptoms, not typically with weight loss or a palpable mass.
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Smarty PANCE Content Blueprint Review:

Covered under ⇒ PANCE Blueprint Renal SystemNeoplastic Diseases of the Renal System (PEARLS)Renal cell carcinoma