A patient describes a history of recurrent bouts of uveitis. Her chemistry panel reveals elevated serum calcium and uric acid levels. Her anergy screen is negative. Her chest x-ray demonstrates bilateral hilar adenopathy. Which diagnosis is most likely?
- Silicosis
- Sarcoidosis
- Alpha-1 antitrypsin deficiency
- Histoplasmosis
- Tuberculosis
Answer: B
Sarcoidosis
Sarcoidosis typically presents with hilar lymphadenopathy and noncaseating granulomas of the lungs (and other organs). In addition, patients may have eye involvement (uveitis). ACE is elevated in about 60% of patients (supportive, not diagnostic); hypercalciuria is common, hypercalcemia occurs in about 10–20%, and uric acid may also be elevated.
Know Your Content Blueprint
Sarcoidosis is part of the NCCPA Content Blueprint Pulmonary System
Review Topic: Sarcoidosis