The Important Side Effects of Anti-Tubercular Drugs
Isoniazid (INH)
- Hepatotoxicity
- B6 deficiencies
- Peripheral neuritis
- Cutaneous hypersensitivity
- Rarely can cause optic neuritis
- Isoniazid is also associated with drug-induced lupus erythematosus
Rifampin (RMP)
- Hepatotoxicity
- Nephrotoxicity
- Red discoloration of the body fluids (which may be alarming but is completely benign)
- Flu-syndrome
- Thrombocytopenic purpura
- Rifampin is a well known P450 inducer and can increase the rate of metabolism of other drugs that are cleared by the liver through the p450 system
Pyrazinamide (PZA)
- Hepatotoxicity
- Hyperuricemia
Ethambutol (ETH)
- This drug can be especially toxic to the eyes, with adverse effects of optic neuritis and red-green color blindness reported
Streptomycin (STM)
- Nephrotoxicity, and ototoxicity
For more information visit the SMARTY PANCE Tuberculosis Lesson and view the interactive ReelDx video case.
