Leukemia and Lymphoma: Comparison Table of Hematologic Malignancies

Leukemia and Lymphoma: Comparison Table of Hematologic Malignancies

A comparison table of the key features differentiating the six PANCE and PANRE hematological malignancies

Lymphomas

Hodgkin's and Non-Hodgkin's Lymphoma are covered as part of the PANCE and PANRE Hematology Blueprint which accounts for 5% of your PANCE and PANRE exam

Hodgkin's Disease Lymphoma Non Hodgkin's Lymphoma
Age Bimodal peaks in 20's then in 50's > 50 years old, increased risk with immunosuppression (ex HIV)
Cell Type Reed-Sternberg Cells are pathognomonic - B cell proliferation with bilobed or multilobed nucleus "owl eye" B Cell: diffuse large B cell

T Cell, natural killer cells

Lymph Node Involvement Painless lymphadenopathy: Upper body lymph nodes: neck, axilla, shoulder, chest (mediastinum)

Contiguous spread to local lymph nodes: usually localized single group of nodes

Peripheral, multiple lymph nodes: axillary, abdominal, pelvic inguinal, femoral.

Non Contiguous, extranodal spread: GI and skin most common

B Symptoms B symptoms are common - fever, weight loss, night sweats B symptoms not common
EBV Association Associate with EBV (40% of patients) Rare
Management Excellent 5 year cure rate (60%) Variable cure rate
Leukemias

These Leukemias are covered as part of the PANCE and PANRE Hematology Blueprint which accounts for 5% of your PANCE and PANRE exam

Acute Myeloid Leukemia (AML) Chronic Myeloid Leukemia (CML) Acute lymphocytic leukemia (ALL) Chronic Lymphocytic Leukemia (CLL)
PEARLS Blasts + Auer Rods in adult patient Strikingly Increased WBC count > 100,000 + hyperuricemia + Adult patient (usually > 50 years old) CHILD + Lymphadenopathy + bone pain + bleeding + fever in a CHILD, bone marrow > 30% blasts in bone marrow Middle age patient, often asymptomatic (seen on blood tests), fatigue, lymphadenopathy, splenomegaly
Epidemiology
  • Most common acute form
  • Average age is 70 y/o
Older males Most common in children (3-7 years old)
  • Most common leukemia in adults
  • > 50 year old
Diagnosis Auer Rods and > 20% blasts seen in bone marrow Philadelphia chromosome (translocation of chromosome 9 and 22) Philadelphia Creacheese", splenomegaly > 30% blasts in bone marrow SMUDGE CELLS on peripheral smear, mature lymphocytes
Treatment Chemotherapy

Bone marrow transplant

PO chemotherapy PO chemotherapy PO chemotherapy

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