A comparison table of the key features differentiating the six PANCE and PANRE hematological malignancies
Lymphomas
Hodgkin's and Non-Hodgkin's Lymphoma are covered as part of the PANCE and PANRE Hematology Blueprint which accounts for 5% of your PANCE and PANRE exam
| Hodgkin's Disease Lymphoma | Non Hodgkin's Lymphoma | |
| Age | Bimodal peaks in 20's then in 50's | > 50 years old, increased risk with immunosuppression (ex HIV) |
| Cell Type | Reed-Sternberg Cells are pathognomonic - B cell proliferation with bilobed or multilobed nucleus "owl eye" | B Cell: diffuse large B cell
T Cell, natural killer cells |
| Lymph Node Involvement | Painless lymphadenopathy: Upper body lymph nodes: neck, axilla, shoulder, chest (mediastinum)
Contiguous spread to local lymph nodes: usually localized single group of nodes |
Peripheral, multiple lymph nodes: axillary, abdominal, pelvic inguinal, femoral.
Non Contiguous, extranodal spread: GI and skin most common |
| B Symptoms | B symptoms are common - fever, weight loss, night sweats | B symptoms not common |
| EBV Association | Associate with EBV (40% of patients) | Rare |
| Management | Excellent 5 year cure rate (60%) | Variable cure rate |
Leukemias
These Leukemias are covered as part of the PANCE and PANRE Hematology Blueprint which accounts for 5% of your PANCE and PANRE exam
| Acute Myeloid Leukemia (AML) | Chronic Myeloid Leukemia (CML) | Acute lymphocytic leukemia (ALL) | Chronic Lymphocytic Leukemia (CLL) | |
| PEARLS | Blasts + Auer Rods in adult patient | Strikingly Increased WBC count > 100,000 + hyperuricemia + Adult patient (usually > 50 years old) | CHILD + Lymphadenopathy + bone pain + bleeding + fever in a CHILD, bone marrow > 30% blasts in bone marrow | Middle age patient, often asymptomatic (seen on blood tests), fatigue, lymphadenopathy, splenomegaly |
| Epidemiology |
|
Older males | Most common in children (3-7 years old) |
|
| Diagnosis | Auer Rods and > 20% blasts seen in bone marrow | Philadelphia chromosome (translocation of chromosome 9 and 22) Philadelphia CreaM cheese", splenomegaly | > 30% blasts in bone marrow | SMUDGE CELLS on peripheral smear, mature lymphocytes |
| Treatment | Chemotherapy
Bone marrow transplant |
PO chemotherapy | PO chemotherapy | PO chemotherapy |
Comprehensive 72 Question PANCE and PANRE Hematology Exam (Members Only)
