PANCE Blueprint Psychiatry (7%)

Non-substance-related addictive disorders (PANRE) (Lecture)

Patient will present as →35-year-old male presents with severe financial difficulties, stress, and relationship problems due to a compulsive need to gamble. He reports significant debt, arguments with his spouse, and job performance issues. Despite repeated attempts, he is unable to stop gambling. The patient is diagnosed with gambling disorder. Treatment includes cognitive-behavioral therapy (CBT), referral to Gamblers Anonymous, possible SSRIs if comorbid depression or anxiety is present, and financial counseling. He is advised to avoid gambling triggers and to seek support from family and friends. Follow-up is scheduled to monitor progress and adjust treatment.

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Non-substance-related addictive disorders (also known as behavioral addictions) include conditions like gambling disorder, internet gaming disorder, and compulsive shopping

  • Share similarities with substance use disorders in terms of psychological and neurobiological mechanisms
  • Common symptoms include compulsive engagement in the behavior, loss of control, withdrawal symptoms, and continued behavior despite negative consequences
  • Prevalence varies by specific disorder; for example, gambling disorder affects about 1% of the general population
  • Risk factors include genetic predisposition, underlying mental health disorders (such as anxiety and depression), social influences, and personality traits (e.g., impulsivity)

Non-substance-related Addictive Disorders vs. Substance Use Disorders

  • Both involve compulsive behaviors and loss of control
  • Non-substance-related disorders do not involve the intake of a psychoactive substance
  • Withdrawal symptoms can occur in both but may differ in nature (e.g., psychological distress vs. physical symptoms)
  • Treatment approaches may overlap but also differ; non-substance-related disorders often benefit from behavioral therapies and support groups, while substance use disorders may require detoxification and medication-assisted treatment.

Diagnosis of non-substance-related addictive disorders is based on clinical evaluation and standardized diagnostic criteria (e.g., DSM-5):

  • Clinical evaluation involves taking a detailed history and focusing on the behavior, its impact on the individual's life, and any associated symptoms.
  • Screening tools, such as the South Oaks Gambling Screen (SOGS) or the Internet Addiction Test (IAT), can be used to assess the severity of the disorder.
  • Standardized Diagnostic Criteria include persistent and recurrent problematic behavior, significant impairment or distress, and at least four of the following:
    • Preoccupation with the behavior
    • An increased amount of time spent on the behavior
    • Repeated unsuccessful attempts to control or reduce the behavior
    • Restlessness or irritability when attempting to cut down
    • Continued behavior despite negative consequences
    • Lying to conceal the extent of the behavior
    • Use of the behavior to escape from problems or relieve dysphoric mood
    • Jeopardizing or losing significant relationships, job, or educational/career opportunities

Treatment typically involves a combination of cognitive-behavioral therapy (CBT), motivational interviewing, and possibly pharmacotherapy

  • Cognitive behavioral therapy (CBT) is the first-line treatment. It helps individuals recognize and change maladaptive thought patterns and behaviors.
  • Motivational interviewing enhances motivation to change the addictive behavior
  • Support groups provide peer support and shared experiences (e.g., Gamblers Anonymous and Internet Gaming Disorder support groups)
  • Pharmacotherapy—There is limited evidence, but some medications may help manage underlying conditions (e.g., Naltrexone, antidepressants for comorbid depression)
  • Family therapy involves family members supporting the individual's recovery and addressing any relational issues
Question 1
A 25-year-old woman has been compulsively shopping online for the past six months, leading to significant financial problems and conflict with her partner. She feels a strong urge to shop and experiences temporary relief after purchasing items, followed by guilt and regret. Which of the following is most likely a risk factor for her behavior?
A
Bipolar disorder
B
Generalized anxiety disorder
Hint:
While anxiety disorders can contribute to compulsive behaviors as a coping mechanism, they are not as strongly associated with compulsive shopping as bipolar disorder. The impulsivity seen in bipolar disorder is a more direct link.
C
Borderline personality disorder
Hint:
Borderline personality disorder can involve impulsive behaviors, but the compulsive nature of shopping and the cycle of relief and guilt are more characteristic of bipolar disorder during manic or hypomanic episodes.
D
Obsessive-compulsive disorder
Hint:
Obsessive-compulsive disorder involves repetitive behaviors driven by intrusive thoughts and the need to reduce anxiety, rather than impulsive behaviors like compulsive shopping, which is more associated with mood disorders.
E
Substance use disorder
Hint:
Substance use disorders involve compulsive use of substances despite negative consequences. While there may be some overlap in impulsive behaviors, compulsive shopping is more closely linked to mood disorders like bipolar disorder.
Question 1 Explanation: 
Bipolar disorder is a significant risk factor for compulsive behaviors, including compulsive shopping, particularly during manic or hypomanic episodes. Individuals with bipolar disorder may experience episodes of elevated mood, increased energy, and impulsive behavior, which can manifest as excessive spending.
Question 2
A 35-year-old woman is diagnosed with gambling disorder. She reports multiple failed attempts to stop gambling and significant financial losses. Which of the following is the most appropriate initial treatment?
A
Selective serotonin reuptake inhibitors (SSRIs)
Hint:
While SSRIs may be helpful for comorbid conditions such as depression or anxiety, they are not the first-line treatment specifically for gambling disorder. CBT directly addresses the behavioral and cognitive aspects of gambling.
B
Cognitive-behavioral therapy (CBT)
C
Antipsychotic medications
Hint:
Antipsychotics are not indicated for the treatment of gambling disorder unless there is an underlying psychotic disorder. They do not address the specific cognitive and behavioral components of gambling disorder.
D
Mood stabilizers
Hint:
Mood stabilizers may be useful for individuals with comorbid bipolar disorder, but they are not the first-line treatment for gambling disorder itself. The primary treatment should focus on behavioral interventions.
E
Inpatient hospitalization
Hint:
Inpatient hospitalization is typically reserved for severe cases with significant risk of harm to self or others, such as severe depression or suicidal ideation. Most patients with gambling disorder can be effectively treated with outpatient therapy, particularly CBT.
Question 2 Explanation: 
Cognitive-behavioral therapy (CBT) is the most appropriate initial treatment for gambling disorder. CBT helps patients identify and change maladaptive thoughts and behaviors related to gambling. It is an evidence-based treatment that has been shown to be effective in reducing gambling behaviors and improving self-control.
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References: UpToDate

Substance-related and addictive disorders (ReelDx) (Prev Lesson)
(Next Lesson) Trauma and stressor-related disorders (PEARLS)
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