Patient will present as → a 28-year-old Caucasian female complaining of a one-week history of fatigue, progressively worsening shortness of breath, and swelling of her feet and ankles. She denies any chest pain. Her past medical history is unremarkable except for a recent cold two weeks prior to this presentation. She denies any past surgical history. She takes oral contraceptive pills as her only medication. She denies any recreational drug use. On physical exam, her temperature is 37 C (98.6 F), blood pressure is 120/70 mmHg, pulse is 84/min, and respiratory rate is 20/min. Her physical exam is also notable for bibasilar crackles, jugular venous distension, an S3 gallop (heard below), and 2+ pitting edema up to the ankles bilaterally. Her electrolytes and complete blood count are within normal limits. CXR reveals cardiomegaly with pulmonary congestion, EKG shows nonspecific ST and T wave changes, and echocardiography demonstrates left ventricular dilation and dysfunction and low cardiac output.
Dilated cardiomyopathy is the most common type (95%) of cardiomyopathy and is a condition in which an index event or process (such as an MI) damages the myocardium, weakening the heart muscle resulting in reduced strength of ventricular contraction, and dilation of the left ventricle.
- Causes include ischemia (CAD, MI, arrhythmia), viral infections, genetic abnormalities (25% to 30%), hypertension, excessive alcohol consumption, postpartum state, chemotherapy toxicity, endocrinopathies, and myocarditis; it may also be idiopathic.
- Dilated cardiomyopathy is characterized by reduced strength of contraction and systolic dysfunction. The result is right and/or left ventricular enlargement and progressive heart failure with increased risk for sudden cardiac death.
- Dilated cardiomyopathy is systolic heart failure (S3 heart sound and low ejection fraction). Will present with acute onset or slowly progressive symptoms. Symptoms include exertional dyspnea, edema, fatigue, loss of appetite, and cough.
Echocardiography is most definitive diagnosis - demonstrates left ventricular dilation and dysfunction and low cardiac output with poor EF (< 50%, but often less than 30%)
- EKG will show nonspecific ST/T wave changes.
- Physical Exam will reveal classic signs of CHF: swelling in legs, lung sounds, and Elevated jugular venous pressure (JVP). Along with cardiomegaly (displaced apical impulse), S3 gallop (third heart sound), and an enlarged liver.
- CXR often shows balloon-like heart - will show cardiomegaly and pulmonary congestion.
Treat just like systolic heart failure:
- βblocker + ACE + Loop Diuretic
- Increase cardiac contractility - Digitalis.
|Dilated cardiomyopathy is a disease of the heart in which the heart becomes weakened and enlarged, and is unable to pump blood efficiently throughout the body. Therefore, it is commonly described as a contractile or systolic dysfunction. This is the most common form of cardiomyopathy not due to ischemic causes. Although many cases are idiopathic, it is thought that dilated cardiomyopathy is related to damage of the myocardium produced by toxic, metabolic, or infectious agents. Common causes of dilated cardiomyopathy include chronic alcohol abuse, wet beriberi related to thiamine deficiency, coxsackie B infection, cocaine use, Chagas disease, doxorubicin toxicity, hemochromatosis and peripartum cardiomyopathy. On physical exam, an S3 heart sound can be appreciated, due to turbulent blood flow between the walls of the ventricles, as blood flows from the atria in the volume overloaded heart. Dilated cardiomyopathy is also characterized by eccentric hypertrophy in which cardiac sarcomeres are added in series as opposed to parallel.|
|Loop diuretics are a class of diuretics that inhibit the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. Furosemide is the generic name for one of the most commonly used loop diuretics, and is also known by the trade name, Lasix. These drugs are sulfa drugs, as they contain a sulfonamide group and can cause allergic reactions in patients with sulfa allergies. Loop diuretics often also lead to electrolyte abnormalities, such as hypokalemia and hypocalcemia. Additionally, these drugs can reduce urate excretion, leading to hyperuricemia, and subsequently gout. Ototoxicity is also a serious, but rare adverse effect of loop diuretics.|
|Selective β1 blockers are drugs which act to block β1 adrenergic receptors and typically treat cardiovascular diseases. They work to block the actions of norepinephrine and epinephrine on cardiovascular contractility, chronotropy and the body's release of renin. These drugs can be remembered by having the "olol" suffix in their names, such as atenolol, esmolol and metoprolol. Some β1 blocking drugs also work as partial β agonists at high doses, such as acebutolol.|
|Nonselective β-blockers were the first generation β-blockers and have antagonistic effects at both β1 (heart, kidney) and β2 receptors (lung, peripheral blood vessels and skeletal muscle) thus preventing direct sympathomimetics such as norepinephrine and epinephrine from binding to these receptors.|
|ACE inhibitors are antihypertensive drugs that work by inhibiting the renin-angiotensin-aldosterone-system. They help to lower blood pressure by inhibiting angiotensin converting enzyme and decreasing the amount of angiotensin II and aldosterone. Effects of inhibiting this conversion are translated into lowered arteriolar resistance, and increased venous capacity. This drug class decrease cardiac output and index, and stroke volume. Furthermore, natriuresis is increased, while there is decreased resistance in the blood vessels of the kidney.
A side effect of these drugs is increased bradykinin, which may display as a persistant dry cough in patients.
enlargement and dilation of all four chambers
enlargement and dilation of the left ventricle
enlargement and dilation of the right ventricle
enlargement and dilation of the right atrium
Viral myocarditis is the second most common cause of non-ischemic cardiomyopathies in the US. (#1 in other parts of the world)
Hypertrophic cardiomyopathy is characterized by a hyperdynamic left ventricle with asymmetric left ventricular hypertrophy.
Restrictive cardiomyopathy is characterized more commonly by right-sided heart failure than by left-sided heart failure. There is rapid early filling with diastolic dysfunction. Patients with restrictive cardiomyopathy will have a small thickened left ventricle and a normal or near normal ejection fraction on echocardiogram.
Takotsubo cardiomyopathy (broken heart syndrome) is characterized by signs and symptoms of acute coronary syndrome, ST segment elevation on ECG and left ventricular apical dyskinesia.