Hyperthyroidism is the production of too much thyroxine hormone. It can increase metabolism and accelerate the body's metabolism, causing unintentional weight loss and a rapid or irregular heartbeat
Etiology: Grave’s disease (autoimmune). Toxic adenoma, thyroiditis, pregnancy, amiodarone
Presentation: Heat intolerance, palpitations, sweating, weight loss, tremor, anxiety, tachycardia
Antithyroid drugs during pregnancy — Propylthiouracil used to be the drug of choice during pregnancy because it causes less severe birth defects than methimazole. But experts now recommend that propylthiouracil be given during the first trimester only. This is because there have been rare cases of liver damage in people taking propylthiouracil. After the first trimester, women should switch to methimazole for the rest of the pregnancy.
Etiology: Hashimoto’s (chronic lymphocytic/autoimmune), previous thyroidectomy/iodine ablation, congenital
Labs: TSH- elevated in primary disease. Low T4 (↑ TSH and ↓ Free T4)
Treatment: Levothyroxine. Follow up with serial TSH monitoring
|Thyroiditis||Thyroiditis is a general term that refers to “inflammation of the thyroid gland”. Thyroiditis includes a group of individual disorders causing thyroidal inflammation but presenting in different ways.