PANCE Blueprint GI and Nutrition (8%)

Rectal Abscess and Fistula (Lecture)

Patient with a rectal abscess will present as → a 45-year-old man presents to the emergency department with a 3-day history of constant, throbbing rectal pain that is worse when sitting and with bowel movements. He also reports fever and malaise. On physical examination, you note a fluctuant, erythematous mass near the anus. The patient is in obvious discomfort.

Patient with an anorectal fistula will present as → a 45-year-old man presents to the clinic with a 3-month history of recurrent perianal abscesses. He reports intermittent drainage of pus and discomfort in the perianal area. On examination, you note a small opening near the anal verge with surrounding erythema. A probe is easily passed through the opening and emerges in the anal canal.

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What disease should be considered with fistula in ano?
Crohn’s disease
What is a sitz bath?
Sitting in a warm bath (usually done after bowel movement and TID)

An anorectal abscess is a collection of pus in the area around the anus and rectum and is the result of infection, whereas an anorectal fistula is an abnormal tunnel that connects the anus or rectum to the skin around the anus and is a chronic complication of an abscess.

  • Most begin as an infected anal crypt gland (cryptoglandular) at the dentate line; perianal abscess is the most common type
  • Abscesses produce constant, painful swelling at the anus as well as painful defecation. Examination reveals localized tenderness, erythema, swelling, and fluctuance; fever is uncommon.
  • Deeper abscesses may produce buttock or coccyx pain and rectal fullness; fever is more likely.

Perianal swelling, erythema, and drainage due to a perianal abscess by the Department of Urology, University Hospital Center, Fez, Morocco. Image - License: CC BY 2.0


An anorectal fistula is an open tract between two epithelium-lined areas and is associated with deeper anorectal abscesses

  • Communication between the rectum and perianal skin
  • Generally located within 3 cm of the anal margin
  • More than 90% are cryptoglandular (follow an abscess, in about a third of patients after drainage); Crohn disease is the key secondary cause — think of it with multiple, recurrent, or complex fistulas
  • Goodsall rule: an external opening posterior to a line across the anus tracks in a curve to the posterior midline; an anterior opening runs straight (radially) into the canal
  • Fistulae will produce anal discharge and pain when the tract becomes occluded

Intraoperative view of the external openings of the fistula in ano (arrowheads) and the upper part of the tract where the foreign material resided (arrow)

Intraoperative view of the external openings of the fistula in ano (arrowheads) and the upper part of the tract where the foreign material resided (arrow) by Department of General Surgery, Cerrahpasa Medical School, Istanbul University, Cerrahpasa, Fatih 34098, Istanbul, Turkey. Image - License: CC BY 3.0

Anorectal fistulas and abscesses are typically diagnosed through a physical examination and medical history

Anal Abscess - Clinical - perirectal tender swollen mass

  • CT or MRI of the pelvis (or endoanal ultrasound) only when a deep abscess is suspected but cannot be seen or felt

Fistula in Ano (perianal fistula)

  • Clinical: external opening ± palpable cord-like tract; confirmed by probing the tract during an exam under anesthesia
  • MRI of the pelvis (or endoanal ultrasound) for complex, recurrent, or Crohn-related fistulas

Treatment of an anorectal abscess requires prompt incision and drainage, followed by warm-water cleansing, analgesics, stool softeners, and a high-fiber diet are prescribed for all patients

  • Prompt incision and adequate drainage are required and should not wait until the abscess points. Many abscesses can be drained as an in-office procedure; deeper abscesses may require drainage in the operating room
  • Antibiotics after drainage for extensive cellulitis, systemic signs or sepsis, diabetes, immunosuppression, or valvular heart disease
  • Packing the cavity is usually not needed

Anorectal fistulas must be treated surgically (antibiotics do not cure them)

  • Simple fistula (low, little sphincter involved) with normal continence → fistulotomy
  • Complex fistula (high, much sphincter involved, multiple, Crohn-related, or existing incontinence) → draining seton first, then a sphincter-sparing repair (LIFT or advancement flap)
Picmonic
Fistula Causes

IM_MED_FistulaCauses_V1.3_

A fistula is a connection or passageway formed abnormally between two epithelium-lined vessels or organs. Causes of enterocutaneous fistulas can be summarized by the mnemonic “FRIEND.” The “FRIENDs” of a fistula include Foreign body, Radiation, Infection, Epithelialization, Neoplasm, and Distal obstruction.

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Question 1
A 38-year-old man had a perianal abscess drained 3 months ago. Since then he has had intermittent, foul-smelling drainage and mild discomfort near the anus. He has no diarrhea, weight loss, or other medical problems. Exam shows a small external opening 2 cm from the anal verge that leaks pus. Which of the following is the most likely underlying cause of this condition?
A
Chronic infection of an obstructed anal crypt gland
B
Ischemia of the posterior midline anoderm
Hint:
Posterior midline ischemia explains a nonhealing anal fissure, not a draining tract.
C
Prolapse of the internal hemorrhoidal cushions
Hint:
Prolapsing hemorrhoids cause painless bleeding and a reducible bulge, not a draining opening.
D
Thrombosis of an external hemorrhoidal vein
Hint:
A thrombosed external hemorrhoid is an acutely painful bluish lump at the anal verge.
E
Transmural granulomatous bowel inflammation
Hint:
Crohn disease is the key secondary cause; suspect it with multiple, recurrent, or complex fistulas or bowel symptoms, which he does not have.
Question 1 Explanation: 
This is a fistula-in-ano. More than 90% are cryptoglandular: an anal crypt gland at the dentate line becomes blocked and infected, forms an abscess, and the tract left after drainage becomes a fistula (this happens in about a third of patients after an abscess). Crohn disease is the most important secondary cause; also think of tuberculosis, radiation, malignancy, and trauma, especially with multiple, recurrent, or complex fistulas.
Question 2
A 32-year-old woman with Crohn disease has recurrent perianal drainage. Exam shows three external openings around the anus, and the tracts cannot be traced with a probe in the office. Which of the following is the most appropriate study to map the fistula tracts before surgery?
A
Anoscopy
Hint:
Anoscopy may show an internal opening but cannot map deep or branching tracts.
B
Barium enema
Hint:
A barium enema shows the colon lumen, not perianal tracts.
C
Computed tomography of the pelvis
Hint:
CT helps find a deep abscess but maps fistula tracts less accurately than MRI.
D
Fistulography
Hint:
Fistulography is uncomfortable and less accurate than MRI; it is rarely used now.
E
Magnetic resonance imaging of the pelvis
Question 2 Explanation: 
Simple fistulas are diagnosed clinically and confirmed by probing the tract during an exam under anesthesia. For complex, recurrent, or Crohn-related fistulas, pelvic MRI (or endoanal ultrasound) is the imaging of choice: it maps the tract in relation to the sphincter muscles and finds hidden abscesses or extensions, which guides surgery and protects continence.
Question 3
A 35-year-old woman has had constant, throbbing pain and swelling next to the anus for 3 days. The pain is worse when she sits. Temperature is 37.9°C (100.2°F). Exam shows a tender, red, fluctuant mass at the anal verge. Which of the following is the most appropriate next step in management?
A
Computed tomography of the pelvis
Hint:
Imaging is for a suspected deep abscess that cannot be felt; this one is obvious on exam.
B
High-fiber diet and sitz baths
Hint:
Supportive care helps after drainage but does not treat the abscess.
C
Incision and drainage
D
Oral antibiotics alone
Hint:
Antibiotics cannot replace drainage of a pus collection.
E
Topical nitroglycerin
Hint:
Nitroglycerin ointment treats anal fissures.
Question 3 Explanation: 
A perianal abscess is diagnosed clinically and treated with prompt incision and drainage, as close to the anal verge as possible, without waiting for fluctuance. Packing is usually not needed. Antibiotics are added after drainage for extensive cellulitis, systemic signs or sepsis, diabetes, immunosuppression, or valvular heart disease (giving them to every patient is debated). A fistula develops in about a third of patients after drainage.
Question 4
A 44-year-old man has had intermittent purulent drainage from an opening beside the anus for 4 months, starting after a perianal abscess was drained. He has normal continence and no bowel symptoms. Exam under anesthesia shows a low intersphincteric fistula tract that involves very little of the sphincter muscle. Which of the following is the most appropriate treatment?
A
Fistulotomy
B
Long-term oral antibiotics
Hint:
Antibiotics do not close an established fistula tract.
C
Rubber band ligation
Hint:
Banding treats internal hemorrhoids.
D
Systemic corticosteroids
Hint:
Steroids do not treat cryptoglandular fistulas.
E
Topical diltiazem
Hint:
Topical diltiazem treats anal fissures.
Question 4 Explanation: 
Fistulas are treated surgically. A simple fistula (superficial, intersphincteric, or low transsphincteric) in a patient with normal continence is laid open with a fistulotomy, which heals more than 90%. Complex fistulas (involving much of the sphincter, high, multiple, Crohn-related, or with existing incontinence) are first drained with a loose seton and then repaired with a sphincter-sparing procedure such as LIFT or an advancement flap.
Question 5
A 58-year-old woman with type 2 diabetes mellitus has a perianal abscess with surrounding cellulitis spreading 5 cm onto the buttock. The abscess is incised and drained in the emergency department. Which of the following is the most appropriate additional management?
A
Antibiotic therapy
B
Daily wound packing
Hint:
Packing after drainage adds pain without improving healing and is not routinely needed.
C
Fistulotomy
Hint:
No fistula has been found; a fistula is treated electively if one develops.
D
Routine wound culture
Hint:
Cultures are not routine; consider them for recurrent abscesses, immunosuppression, or suspected MRSA.
E
Topical nifedipine
Hint:
Nifedipine ointment treats anal fissures.
Question 5 Explanation: 
Drainage is the main treatment for every anorectal abscess. Antibiotics are clearly indicated after drainage when there is extensive cellulitis, systemic signs or sepsis, diabetes, immunosuppression, or valvular heart disease; routine antibiotics for every patient are debated. This patient has two of these indications (diabetes and spreading cellulitis), so she needs antibiotics after drainage.
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References: Merck Manual · UpToDate

Brian Wallace PA-C Podcast: The Rectum, Hemorrhoids and Hernias (Prev Lesson)
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