PANCE Blueprint Pulmonary (10%)

Pulmonary Circulation (PEARLS)

The NCCPA™ PANCE  Pulmonary Content Blueprint addresses three types of pulmonary circulation disorders

Cor pulmonale
Patient will present as → 65 y/o with 3 days of progressive dyspnea and purulent sputum production. The patient takes albuterol and tiotropium bromide for moderate COPD. His PMH is relevant for a 40 pack-year smoking history, type II DM, hyperlipidemia, and coronary artery stenting 2 years ago. PE shows barrel-shaped chest, inspiratory crackles, hepatojugular reflux, pulsus paradoxus, and ventricular gallop. His temperature is 38.1°C (100.5°F), the pulse is 130/min, respirations are 28/min, blood pressure is 130/84 mmHg, and pulse oximetry on room air shows an oxygen saturation of 86%.

Right ventricular enlargement and eventually failure secondary to lung disorder that causes pulmonary artery HTN

DX: EKG: S1Q3T3

  • Echocardiogram or radionuclide imaging; sometimes right heart catheterization

TX: Diagnose and treat the underlying condition before cardiac structure change becomes irreversible

    • Diuretics are not helpful and may be harmful!

s1q3t3

Pulmonary embolism (ReelDx)
Patient will present as → 68 y/o F who underwent hip replacement surgery two weeks ago. The postoperative period was complicated by pneumonia, and the patient has been bed-ridden ever since. A nurse calls you to the patient’s room due to vital sign abnormalities and complaints of chest pain. The patient’s HR is 105 bpm, BP is 90/60 mmHg, RR is 35 rpm, and T is 100.2F. You note jugular venous distension and profound dyspnea. Upon auscultation, you notice tachypnea and crackles.

Pulmonary embolism is a blockage in one of the pulmonary arteries in the lungs

  • More than 90% originate from clots in the deep veins of the lower extremities
  • Presents with dyspnea (most common) and pleuritic chest pain
  • R/F: Virchow’s triad = hypercoagulable state, trauma, venostasis (surgery, cancer, oral contraceptives, pregnancy, smoking long bone fracture/fat emboli)
  • Homan’s sign: (Dorsiflexion of the foot causes pain in calf) indicative of deep vein thrombosis
  • EKG: TACHYCARDIA (most common), S1Q3T3 (rare), non-specific ST wave changes

Diagnosis: Well’s Score is used to assess the probability of pulmonary embolism

  • Spiral CT = initial method of identifying
  • Pulmonary angiography = gold standard definitive
  • CXR: Westermark sign or Hampton hump (triangular or rounded pleural base infiltrate adjacent to hilum)
  • VQ scans are "old school"= perfusion defects with normal ventilation (normal VQ rules out PE; abnormal – non-specific)
  • Venous duplex ultrasound of lower extremities (normal test does not exclude PE)
  • ABG = respiratory alkalosis secondary to hyperventilation
  • D-dimer

Tx: Heparin is the anticoagulant of choice for the acute phase with factor Xa inhibitors (eg, rivaroxaban, apixaban, edoxaban) and oral direct thrombin inhibitors (dabigatran) thereafter

Pulmonary hypertension
Patient will present as → 43 y/o F with a history of COPD presents to the office with worsening dyspnea, especially at rest. She also complains of dull, retrosternal chest pain. On examination, she has persistent widened splitting of S2. Radiographic findings (seen here) demonstrate peripheral “pruning” of the large pulmonary arteries.

Blood pressure in the lungs is usually very low 15/5. In pulmonary hypertension, the pressure increases > 25 mmHg at rest

  • Usually caused by an underlying disorder (constrictive pericarditis, mitral stenosis = MC, LV failure, mediastinal disease compression pulmonary veins)
    • Mitral stenosis: mitral valve = tight so blood can’t pass into left ventricle ⇒ pressure backs up to lungs
  • When the right heart can’t pump against vascular resistance ⇒ right heart failure = cor pulmonale
  • Presentation: Dyspnea on exertion, fatigue, chest pain, edema
  • Physical Exam: Loud pulmonic component of second heart sound (P2); Jugular venous distension; Ascites; Hepatojugular reflux; Lower limb edema

Diagnose with a right heart catheterization (gold standard)  → most accurate measure of pressures

  • CXR
    • Enlarged pulmonary arteries
    • Lung fields may or may not be clear, dependent on the underlying cause
  • Echocardiogram
    • Increased pressure in pulmonary arteries, right ventricles → dilated pulmonary artery
    • Dilatation/hypertrophy of right atrium, right ventricle
    • Large right ventricle → bulging septum
  • ECG → Right heart strain pattern: T wave inversion in right precordial (V1–V4), and inferior leads (II, III, aVF)

TX: identify and treat the underlying cause

Pneumothorax (ReelDx) (Prev Lesson)
(Next Lesson) Brian Wallace PA-C Podcast: Pulmonary Circulation
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