2019 PANRE and Pilot Alternative to PANRE Interactive Content Blueprint

Content Blueprint for the Physician Assistant National Recertifying Examination (PANRE) and the Pilot Alternative to PANRE

Organized by Content Category

The diseases and disorders that may be covered on PANRE and the Pilot Alternative to PANRE are provided below. Also provided is the level at which each disease and disorder will be assessed. The levels are defined as follows:

  • Level 1: Recognize most likely diagnosis using signs, symptoms, and risks; refer appropriately.
  • Level 2: Make appropriate diagnosis by recognizing signs, symptoms, risks and/or interpreting results of diagnostic studies, and have knowledge of first-line treatment.
  • Level 3: Make appropriate diagnosis by recognizing signs, symptoms, risks and/or interpreting the results of diagnostic studies and have knowledge of first-line treatment. In addition, have the knowledge required to manage well- known comorbid conditions, contraindications, and complications.

Information on how the blueprint was developed may be accessed on the NCCPA website.

Content Area Percent Allocation*
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Cardiovascular System 13%
Dermatologic System 6%
Endocrine System 6%
Eyes, Ears, Nose, and Throat 8%
Gastrointestinal System/Nutrition 11%
Genitourinary System 5%
Hematologic System 4%
Infectious Diseases 6%
Musculoskeletal System 9%
Neurologic System 7%
Psychiatry/Behavioral Science 5%
Pulmonary System 10%
Renal System 3%
Reproductive System 7%

Content Category

Cardiovascular System: 13%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Abdominal aortic aneurysm
Acute myocardial infarction: non–ST-segment elevation myocardial infarction (NSTEMI)
Acute myocardial infarction: ST-segment elevation myocardial infarction (STEMI)
Acute pericarditis
Acute/subacute bacterial endocarditis
Angina pectoris (stable angina)
Aortic dissection
Aortic stenosis
Arterial embolism/thrombosis
Atrial fibrillation
Atrial flutter
Atrioventricular block­
Bundle branch block
Cardiac tamponade
Cardiogenic shock
Coronary artery disease
Deep venous thrombosis
Diastolic heart failure
Dilated cardiomyopathy
Essential hypertension (in adults)
Hypercholesterolemia
Hypertensive emergency
Hypertriglyceridemia
Hypertrophic cardiomyopathy
Iliac artery occlusion
Mitral regurgitation
Mitral valve prolapse
Orthostatic hypotension
Paroxysmal supraventricular tachycardia
Pericardial effusion
Peripheral artery disease
Phlebitis/thrombophlebitis
Premature atrial/ventricular contractions
Prinzmetal variant angina
Secondary hypertension
Sick sinus syndrome
Systolic heart failure
Temporal arteritis
Thoracic aortic aneurysm
Torsades de pointes
Unstable angina
Varicose veins
Venous insufficiency
Ventricular fibrillation
Ventricular tachycardia
Cardiology Exam Take Exam
Dermatologic System: 6%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acne vulgaris
Actinic keratosis
Acute urticaria, Drug eruptions
Atopic dermatitis
Basal cell carcinoma
Burns
Cellulitis, Erysipelas
Contact dermatitis
Erythema multiforme
Herpes simplex virus
Hidradenitis suppurativa
Impetigo
Lipomas/epidermal inclusion cysts
Melanoma
Molluscum contagiosum
Onychomycosis, Dermatophyte infections
Paronychia
Pilonidal disease
Pityriasis rosea
Pressure ulcers
Psoriasis
Rosacea
Scabies, Lice infestation
Seborrheic dermatitis
Spider bites
Squamous cell carcinoma
Toxic epidermal necrolysis, Stevens-Johnson syndrome
Dermatology Exam Take Exam
Endocrine System: 6%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Benign thyroid nodules
Cushing syndrome
Diabetes insipidus
Hyperparathyroidism
Hyperthyroidism/thyrotoxicosis
Hypoparathyroidism
Hypothyroidism
Metabolic syndrome and obesity
Osteoporosis
Primary adrenal insufficiency
Thyroid cancer
Thyroiditis
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Endocrine System Exam Take Exam
Eyes, Ears, Nose, and Throat: 8%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute epiglottitis
Acute pharyngitis
Acute/chronic otitis media
Acute/chronic sinusitis­
Allergic rhinitis
Aphthous ulcers
Blepharitis
Cataract
Chalazion
Conjunctivitis
Corneal abrasion
Corneal ulcer
Epistaxis
Eustachian tube dysfunction
Foreign body in ear
Foreign body in eye
Foreign body in nose
Glaucoma
Hearing loss
Hordeolum
Hyphema
Labyrinthitis
Laryngitis
Mastoiditis
Meniere disease
Nystagmus
Oral candidiasis
Oral leukoplakia
Orbital blowout fracture
Orbital cellulitis
Otitis externa
Papilledema
Parotitis
Peritonsillar abscess
Retinal detachment
Tinnitus
Tympanic membrane perforation
Vertigo
Eyes, Ears, Nose, and Throat Exam Take Exam
Gastrointestinal System/Nutrition: 11%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute hepatitis
Acute/chronic cholecystitis
Acute/chronic pancreatitis
Anal abscess/fistula
Anal fissure
Appendicitis
Celiac disease
Cholangitis
Cholelithiasis
Chronic hepatitis
Cirrhosis
Colon cancer
Constipation
Diverticulitis/diverticulosis
Esophageal varices
Esophagitis
Fecal impaction
Food allergies
Foreign body ingestion
Gastritis
Gastroesophageal reflux disease
Hemorrhoids
Hernias
Infectious diarrhea
Inflammatory bowel disease
Ingestion of caustic substance
Intentional overdose of medication
Intussusception
Irritable bowel syndrome
Ischemic bowel disease
Large-bowel obstruction
Mallory-Weiss tear
Noninfectious diarrhea
Peptic ulcer disease
Pyloric stenosis
Small-bowel obstruction
Toxic megacolon
GI and Nutrition Exam Take Exam
Genitourinary System: 5%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute prostatitis
Bacterial cystitis
Benign prostatic hyperplasia
Bladder cancer
Chronic prostatitis
Epididymitis
Erectile dysfunction
Fecal incontinence
Hydrocele/varicocele
Nephrolithiasis/urolithiasis
Orchitis
Paraphimosis/phimosis
Prostate cancer
Testicular cancer
Testicular torsion
Urethritis
Urinary incontinence
Genitourinary System Exam Take Exam
Hematologic System: 4%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute/chronic lymphocytic leukemia
Anemia of chronic disease
Factor V Leiden hypercoagulability
Folate deficiency anemia
Hemolytic anemia
Hodgkin lymphoma
Hypocoagulable states
Iron deficiency anemia
Non-Hodgkin lymphoma
Sickle cell anemia
Thrombotic thrombocytopenic purpura
Vitamin B12 deficiency anemia
Hematologic System Exam Take Exam
Infectious Diseases: 6%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute rheumatic fever
Chickenpox/herpes zoster
Chlamydial infections
Epstein-Barr virus infections
Gonococcal infections
HIV infection
Human papillomavirus infections
Influenza
Lyme disease
Measles
Mumps
Pinworm infestation
Rabies
Rocky Mountain spotted fever
Roseola
Rubella
Syphilis
Tetanus
Tuberculosis
Vaginal candidiasis
Musculoskeletal System: 9%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute/chronic osteomyelitis
Avascular necrosis
Back strain/sprain, Lower back injuries
Biceps tendinitis
Carpal tunnel syndrome
Cauda equina syndrome
Compartment syndrome
de Quervain tenosynovitis
Fibromyalgia
Fractures and dislocations: knee/patella, ankle/foot, forearm/wrist/hand, shoulder, hipspine
Ganglion
Gout/pseudogout
Kyphosis
Lateral and medial epicondylitis
Osgood-Schlatter disease
Osteoarthritis
Rheumatoid arthritis
Rotator cuff tear
Scoliosis
Septic arthritis
Shoulder bursitis
Shoulder tendinitis
Slipped capital femoral epiphysis
Soft-tissue injuries of the knee, foot/ankle, forearm/wrist/hand
Spinal disk herniation
Spinal stenosis
Systemic lupus erythematosus
Musculoskeletal System Exam Take Exam
Neurologic System: 7%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Cerebral aneurysm
Cluster headache
Concussion
Delirium
Encephalitis
Essential tremor
Guillain-Barré syndrome
Major neurocognitive disorder/dementia
Meningitis
Migraine
Multiple sclerosis
Parkinson disease
Peripheral neuropathy
Postconcussion syndrome
Radiculopathy
Seizure disorders
Spontaneous intracranial hemorrhage
Status epilepticus
Stroke/transient ischemic attack
Syncope
Tension headache
Traumatic intracranial hemorrhage
Neurologic System Exam Take Exa2m
Psychiatry/Behavioral Science: 5%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Anorexia nervosa, Bulimia nervosa
Attention-deficit/hyperactivity disorder
Bereavement/grief reaction
Bipolar disorder
Child/elder abuse, Spouse/partner abuse
Generalized anxiety disorder
Major depressive disorder
Non–substance-related addictive disorders
Panic disorder
Post-traumatic stress disorder
Substance use disorders: illicit substances, prescription drugs, alcohol, tobacco
Suicide risk
Psychiatry and Behavioral Science Exam  Take Exam
Pulmonary System: 10%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acute bronchiolitis
Acute bronchitis
Acute respiratory distress syndrome
Asthma
Bacterial pneumonia
Chronic bronchitis
Croup
Emphysema
Foreign body aspiration
Lung cancer
Pertussis
Pleural effusion
Pneumothorax
Pulmonary embolism
Pulmonary nodules
Respiratory syncytial virus infection
Sleep apnea
Viral pneumonia
Pulmonary System Exam Take Exam
Renal System: 3%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Acid-base disorders
Acute kidney injury (acute renal failure)
Chronic kidney disease
Electrolyte disorders
Pyelonephritis
Reproductive System: 7%*
Smarty PANCE is not sponsored or endorsed by, or affiliated with, the National Commission on Certification of Physician Assistants
Diseases and Disorders Level 1 Level 2 Level 3
Abruptio placentae
Amenorrhea
Breast abscess
Breast cancer
Cervical cancer
Cervicitis
Contraception
Dysfunctional uterine bleeding
Dysmenorrhea
Ectopic pregnancy
Endometriosis
Gestational diabetes
Hypertension disorders in pregnancy
Mastitis
Menopause
Ovarian cysts
Pelvic inflammatory disease
Placenta previa
Postpartum hemorrhage
Premature rupture of membranes
Premenstrual syndrome
Prenatal diagnosis and care/preconception counseling
Rh incompatibility
Sexual/physical abuse in pregnancy
Vaginitis
Reproductive System Exam Take Exam

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